Discover and read the best of Twitter Threads about #CovidTimes
Most recents (1)
1/ Awesome 🤩: RCTs coming out answering important questions on Covid19!
A trial designed/coordinated by 🇧🇷 trialists @RenatoDLopes1 @damiani_petri Pedro Barros
DSMB chaired by Alexandre Biasi, who I luckily can call a friend
thread:
jamanetwork.com/journals/jama/… @JAMA_current
A trial designed/coordinated by 🇧🇷 trialists @RenatoDLopes1 @damiani_petri Pedro Barros
DSMB chaired by Alexandre Biasi, who I luckily can call a friend
thread:
jamanetwork.com/journals/jama/… @JAMA_current
2/ Why this trial was needed? 🧐
ACE2 is the receptor for SARS-CoV-2
Select preclinical investigations have shown upregulation of ACE2 by RAAS inhibitors (such as ACEIs and ARBs), raising concerns about their safety in patients with COVID-19
science.sciencemag.org/content/367/64…
ACE2 is the receptor for SARS-CoV-2
Select preclinical investigations have shown upregulation of ACE2 by RAAS inhibitors (such as ACEIs and ARBs), raising concerns about their safety in patients with COVID-19
science.sciencemag.org/content/367/64…
3/ A multicenter open-label RCT with blinded end-point assessment was performed:
POPULATION: 659 pts hospitalized with COVID-19 who were taking ACEIs or ARBs prior to hospital admission (mild and moderate Covid19)
INTERVENTION: discontinuation vs continuation RAAS inhibitors
POPULATION: 659 pts hospitalized with COVID-19 who were taking ACEIs or ARBs prior to hospital admission (mild and moderate Covid19)
INTERVENTION: discontinuation vs continuation RAAS inhibitors
