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Let's talk about YEAST!

🤔What are they
🤒Which ones cause human disease
🧫How do we ID them in the lab
💊What are the treatment options (including mechanisms & resistance to anti-fungals)

#IDtwitter #MicroMedEd Yeastie Beasties talk, May 2021
Yeast are a type of fungi (so are moulds&🍄).

"Yeast" isn't a taxonomic group, it describes how they appear. Single-celled like bacteria, but eukaryotic. (More here )

Thanks Saccharomyces for your sourdough bread. (And my beer🍻)

nature.com/articles/nrmic… Comparison of the morphology of yeast, mould hyphae, conidiaComparison of morphology of moulds vs yeast (for dimorphic f
Yeast come in many shapes & sizes, and there are mimics that can look like yeast on microscopy.

🔬The CLSI M54 categorizes yeast by size, and I love their approach, expanded here: An approach to yeast & yeast-like microbes, by size (small v
Read 26 tweets
CASO CLINICO
Masc 33 años, consulta en Urgencias. Cefalea + nauseas + dism edo alerta + convulsión de 3 semanas. Exp: Rigidez nuca, 2 adenop cervicales 1 cm, Babinsky +.

Labs: Hb 7.8, Plq 178 mil, Leu 5.2; Cr 1.27 BUN 42. HIV test +. ImageImageImage
Se realiza PL con LCR claro; PA 32 cmH2O; Cel 21; Glu 23 (Central 122); Prot 99.
Tinciones Gram/ZN/India Ink
Cultivo LCR/Hemo: En incubación
GeneXpert RIF assay en LCR neg

En la microscopia se encuentra la siguiente imagen. Image
¿Cuál es el mejor tratamiento que le podemos ofrecer a este paciente?
Read 23 tweets

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