Discover and read the best of Twitter Threads about #D68
Most recents (4)
ICYMI—the CDC put out a nationwide warning about an outbreak of enterovirus #D68 last week. Between all the DOJ investigations & royal news, you probably missed it. But hospital pediatric beds are filling up with with this respiratory outbreak.
2) Yes, doctors report PICU hospital beds are full.
3) Here is the CDC warning— EV-D68 — a virus that in rare cases can trigger a polio-like syndrome — is circulating. That could presage a surge in cases of acute flaccid myelitis or #AFM in the coming weeks, experts warn.
emergency.cdc.gov/han/2022/han00…
emergency.cdc.gov/han/2022/han00…
Huge thanks to @HopkinsMedicine @AmaryFaln @hmostaf2 for sending along the first #Enterovirus #D68 #EVD68 sequences of 2022! 🙏🏻🚀
You can see them in the full-genome & VP1 builds:
nextstrain.org/enterovirus/d6…
nextstrain.org/enterovirus/d6…
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You can see them in the full-genome & VP1 builds:
nextstrain.org/enterovirus/d6…
nextstrain.org/enterovirus/d6…
1/5
Note that for the moment I don't have anything but year for these sequences, so month is being inferred by the pipeline - note the wide confidence interval on the date!
However, zooming into the VP1 build, we can see some interesting connections...
2/5
However, zooming into the VP1 build, we can see some interesting connections...
2/5
All part of the B3 clade, 1 seq attaches to autumn 2021 circulation in Europe/USA (1), 1 attaches back to European circulation in autumn 2019 (2), and the rest attach back to USA+ circulation in autumn 2019 (3).
3/5
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📡#Enterovirus #D68 #EVD68 builds on @nextstrain are now updated 📡
You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).
I'll give a brief overview of a few things of interest...
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You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).
I'll give a brief overview of a few things of interest...
1/7
The VP1 #EVD68 build lets us include the most sequences, so I'll focus on that here - though full-genome has many other advantages!
No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.
2/7
No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.
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And more specifically, are related to seq clusters that circulated in 2018/2019.
Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!
3/7
Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!
3/7
Recently I've heard from collaborators in the US & Europe that #Enterovirus #D68 #EVD68 cases are on the rise.
EV-D68 is what I worked on pre-pandemic, & hope to go back to.
A significant autumn 2022 wave has been a recent concern.
So what is D68 & what might this mean?
1/17
EV-D68 is what I worked on pre-pandemic, & hope to go back to.
A significant autumn 2022 wave has been a recent concern.
So what is D68 & what might this mean?
1/17
#EVD68 is a Picornavirus - a diverse family of viruses. And Enteroviruses are pretty diverse themselves: from Poliovirus, which can cause serious neurological illness, to Rhinovirus - what's behind the common cold 🤧 (and even more in between).
2/17
2/17
One of the most notable things about #EVD68 is that in Europe & North America it's historically had biennial autumn outbreaks: in 2014, 2016, & 2018. Also predicted in 2020... but that didn't happen due to pandemic!
Following that pattern, 2022 would be an outbreak season🗓️
3/17
Following that pattern, 2022 would be an outbreak season🗓️
3/17
