Discover and read the best of Twitter Threads about #DEMENTIA
Most recents (24)
Today an influential but sadly flawed 'consensus' pours water on adverse #BrainHealth risk and #neurodegenerative disease/ #dementia in former contact sport athletes.
Meanwhile ⬇️
Meanwhile ⬇️
"But it's a consensus of experts!"
Nobody can be an expert on everything, not even #CISG
Recognising this, Statement authors commissioned reviews by selected specialist 'expert' authors to review literature*, led by small subgroups of #CISG panel
1/
Nobody can be an expert on everything, not even #CISG
Recognising this, Statement authors commissioned reviews by selected specialist 'expert' authors to review literature*, led by small subgroups of #CISG panel
1/
These sub-groups then fed back outcomes from the review processes, which wider Statement authors voted on, so producing 'consensus' positions.
What does this mean?
It means that for late effects, by example, only 7/31 Statement authors actually reviewed the literature
2/
What does this mean?
It means that for late effects, by example, only 7/31 Statement authors actually reviewed the literature
2/
Ten lesser-known symptoms that could point towards a diagnosis of brain tumor
June 8th is celebrated as “World brain tumor day” to raise awareness about brain tumors. I would like to focus on the symptoms, presence of which, can make one suspect the presence of brain tumor. twitter.com/i/web/status/1…
June 8th is celebrated as “World brain tumor day” to raise awareness about brain tumors. I would like to focus on the symptoms, presence of which, can make one suspect the presence of brain tumor. twitter.com/i/web/status/1…
Common symptoms of brain tumor include headache, vomiting, reduced alertness, fits & paralysis. However, in several cases, these classical symptoms may be missing. It is important to know the lesser-known symptoms of brain tumors so that they can be diagnosed & treated early.
1. Increase in hat and shoe size over time- A tumor of pituitary gland of brain producing excess growth hormone (GH) causes a condition known as acromegaly, which can result in increasing head and feet size, necessitating a need for larger hats and bigger shoes.
2/ The heartbreak we see has scientists working to discover answers💔
Drs. @VirusesImmunity & @PutrinoLab explore hypotheses
📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation
Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v
Drs. @VirusesImmunity & @PutrinoLab explore hypotheses
📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation
Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v
3/ Data from 223 unvaxxed Mild/Mod COVID survivors
✔️ Show abnormal MRI 🧠 white matter inflammation at 9 mo vs matched controls
✔️Prolonged cellular changes occur & we don’t yet know the significance
✔️Clinical outcomes vary strikingly across studies
bit.ly/43f0vL2
✔️ Show abnormal MRI 🧠 white matter inflammation at 9 mo vs matched controls
✔️Prolonged cellular changes occur & we don’t yet know the significance
✔️Clinical outcomes vary strikingly across studies
bit.ly/43f0vL2
4/ Brain inflammation in other types of #Dementia…
🔸Is often present YEARS before memory & executive dysfunction deficits appear
🔸Don’t be complacent or assume #LongCOVID is safe for peoples’ brains
🔸It’s precarious!
🔸 I covered this haunting brain science in 🧵👇
🔸Is often present YEARS before memory & executive dysfunction deficits appear
🔸Don’t be complacent or assume #LongCOVID is safe for peoples’ brains
🔸It’s precarious!
🔸 I covered this haunting brain science in 🧵👇
1/🧵 Long COVID’s “Disability Roulette”
🔺No longer a mass Death event…
🔺COVID-19 is an ongoing mass #Disability event
🔺You & I might get #LongCOVID
🔺But society is yawning
This thread unpacks science, policy & hope.
No Paywall Boston Globe link:
bit.ly/3OGfSb1
🔺No longer a mass Death event…
🔺COVID-19 is an ongoing mass #Disability event
🔺You & I might get #LongCOVID
🔺But society is yawning
This thread unpacks science, policy & hope.
No Paywall Boston Globe link:
bit.ly/3OGfSb1
Friends, I have an entire 20 tweet thread 🧵 uploading here (links, PDF images, etc etc -
but it’s stuck in twitter world.
I apologize for the glitch here. Oy!
but it’s stuck in twitter world.
I apologize for the glitch here. Oy!
2/ The heartbreak we see has scientists working to discover answers💔
Drs. @VirusesImmunity & @PutrinoLab explore hypotheses
📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation
Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v
Drs. @VirusesImmunity & @PutrinoLab explore hypotheses
📍viral persistence
📍vital reactivation
📍autoimmunity
📍inflammation
Testing antivirals, immune modulators, blood thinners. bit.ly/45E1F4v
Type 2 diabetes is associated with increased risk of developing dementia
1. Those diagnosed with diabetes before age 60 years had a nearly threefold increased risk for dementia compared to those who never developed diabetes, as per a recent study.
#MedTwitter #diabetes twitter.com/i/web/status/1…
1. Those diagnosed with diabetes before age 60 years had a nearly threefold increased risk for dementia compared to those who never developed diabetes, as per a recent study.
#MedTwitter #diabetes twitter.com/i/web/status/1…
2. Those aged 60-69 years at diabetes diagnosis had 73% higher risk of developing dementia and those aged 70-79 years at diabetes diagnosis had 23% higher risk of developing dementia.
The relationship with dementia was not significant for those aged 80 years and older.
#dementia
The relationship with dementia was not significant for those aged 80 years and older.
#dementia
3. Mechanisms include glucose toxicity, insulin resistance & microvascular dysfunction of the central nervous system.
Glucose toxicity and microvascular dysfunction are associated with increased inflammatory & oxidative stress, leading to increased blood–brain permeability.
Glucose toxicity and microvascular dysfunction are associated with increased inflammatory & oxidative stress, leading to increased blood–brain permeability.
Hot Rod Lincoln ~ Phase Separation
Spontaneous Nucleation and Fast Aggregate-Dependent Proliferation of a-Synuclein
Spontaneous Nucleation and Fast Aggregate-Dependent Proliferation of a-Synuclein
Typical blood pH is 7.35 - 7.45
Phase separation and neurodegeneration
In May 2019, Dr. @rschilsky & I co-chaired the #AAADV19 Workshop Plenary Session "Decentralized #ClinicalTrials: The Future is Now." An incredible group of panelists from academia, industry, govt, & patient #advocacy 👇discussed the rationale, challenges, & opportunities of DCTs.
No one knew yet that the #COVID19 #pandemic was just around the corner. In Mar 2020, FDA released a guidance on conduct of #clinicaltrials during the pandemic: fda.gov/media/136238/d…, & colleagues wrote about the impact on #OncTwitter trials: ncbi.nlm.nih.gov/pmc/articles/P…. /2
FDA has now released a draft guidance on decentralized #clinicaltrials for drugs, biological products, & devices covering #telehealth, remote assessments, consent, shipping of IP, & more: fda.gov/media/167696/d…. #MedTwitter #regulatory #drugdevelopment
🏴 Scotland has reported 14 consecutive months of #ExcessDeath - from March 2022
🏴 Scotland has reported 24 months of excess death (out of 28) since the COVID-19 vaccine was rolled out in December 2020
Over 14,000 excess deaths since 8/12/2020
What is causing it Humza Yousaf?
🏴 Scotland has reported 24 months of excess death (out of 28) since the COVID-19 vaccine was rolled out in December 2020
Over 14,000 excess deaths since 8/12/2020
What is causing it Humza Yousaf?
🚨🚨Pandemic of non-covid excess deaths in 🏴
23,395 deaths in 2023
2,344 excess deaths
+11.1%
#Circulatory 💔
5,838 deaths
501 excess
9.4%
#Cancer
5,523
211 excess
4%
#Dementia
2,464
208 excess
9.2%
#OTHER
5,938
1,062 excess
21.8%
#COVID19
737
3.2% of all deaths in 2023
23,395 deaths in 2023
2,344 excess deaths
+11.1%
#Circulatory 💔
5,838 deaths
501 excess
9.4%
#Cancer
5,523
211 excess
4%
#Dementia
2,464
208 excess
9.2%
#OTHER
5,938
1,062 excess
21.8%
#COVID19
737
3.2% of all deaths in 2023
There have been over 15 Million doses of the COVID-19 vaccines administered in 🏴Scotland since 8/12/2020
Since then, there have been over 10,000 deaths attributed to ‘COVID’ ….
…. mostly amongst the vaccinated …😬
Since then, there have been over 10,000 deaths attributed to ‘COVID’ ….
…. mostly amongst the vaccinated …😬
Concerns regarding exploitation of the #agedcare funding system & repeated calls for accountability & transparency R well founded. A brief (by all means not comprehensive) history on #rorting or 'maximising' in aged & home care @JasonWardCICTAR @anmf_federal
(2012) Nursing homes: The manner in which govt was prepared to turn a blind eye to #rorting in #agedcare was revealed when employees in the Health dept blew the whistle on ABC @4corners in 2012 web.archive.org/web/2019070807…
1. Today at work: Conversed with patients in Tamil, Telugu, Bangla, Hindi, English, Somali & Arabic during ward/ICU rounds & OPD.
Brought smiles on patient's faces as well. I love interacting with people/patients in their own languages as they love listening to own languages. twitter.com/i/web/status/1…
Brought smiles on patient's faces as well. I love interacting with people/patients in their own languages as they love listening to own languages. twitter.com/i/web/status/1…
2. I have seen agitations against various languages in many states, which are futile. It is always good to learn more languages, as it is a win-win situation.
(below pictures are from the internet)
(below pictures are from the internet)
3. Speaking two languages, moreover, delays the age of onset of dementia by an average of 4.5 years. This benefit is seen in educated as well as illiterate people. doi.org/10.1212/01.wnl…
Regular internet usage is associated with lower risk of dementia in older people
1. The prevalence of dementia is increasing with an increase in longevity. Prevention is preferred as there is no cure for Alzheimer's disease.
#dementia #MedTwitter #NeuroTwitter #Internet
1. The prevalence of dementia is increasing with an increase in longevity. Prevention is preferred as there is no cure for Alzheimer's disease.
#dementia #MedTwitter #NeuroTwitter #Internet
2. 18,154 adults aged 50-65 were followed up for a maximum of 17.1 (median=7.9) years.
Regular internet usage was associated with approximately half the risk of dementia compared to non-regular usage.
Educational status did not play any role in this association.
Regular internet usage was associated with approximately half the risk of dementia compared to non-regular usage.
Educational status did not play any role in this association.
3. In addition, additional periods of regular usage were associated with significantly reduced dementia risk.
However, estimates for daily hours of usage suggested a U-shaped relationship with dementia incidence. The lowest risk was observed among adults with 0.1-2 hours of usage
However, estimates for daily hours of usage suggested a U-shaped relationship with dementia incidence. The lowest risk was observed among adults with 0.1-2 hours of usage
Tony Ferrante MD PhD of @ColumbiaMed providing an excellent systems based overview of the "metabolic" complications of #obesity and potential mechanisms: lipotoxicity, inflammation, adipokines
Some highlights:
1/
Some highlights:
1/
Neurology:
Check out this relationship where higher BMI is associated with ↑ risk of #dementia EXCEPT in age >70 when it's better to be in "overweight" category
👉Aiming for a "normal BMI" is not the best goal for everyone
2/
Check out this relationship where higher BMI is associated with ↑ risk of #dementia EXCEPT in age >70 when it's better to be in "overweight" category
👉Aiming for a "normal BMI" is not the best goal for everyone
2/
In order for ketogenic diets to be offered as a treatment for Alzheimer's disease and covered by insurance, several things would need to happen. (1/11)
First, large-scale clinical trials would need to be conducted to demonstrate the safety and efficacy of ketogenic diets for Alzheimer's disease. (2/11)
These trials would need to include diverse patient populations and be well-designed to control for confounding variables. (3/11)
Day 2 @theNASEM workshop
The highlight from day 1: LaToya, a CNA, gave a moving, honest, courageous account of being a direct care worker. “The ice cream truck should not be a luxury.”
- hours & pay are bad, the work is hard & they love & care their patients & their dignity
The highlight from day 1: LaToya, a CNA, gave a moving, honest, courageous account of being a direct care worker. “The ice cream truck should not be a luxury.”
- hours & pay are bad, the work is hard & they love & care their patients & their dignity
@theNASEM First up- @EspinozaNotes from @PHInational
The intense focus on direct care workers, paying people a living wage, improving working conditions so that we can also improve patient care during this event has given me so much hope
The intense focus on direct care workers, paying people a living wage, improving working conditions so that we can also improve patient care during this event has given me so much hope
“Social determinants of success at work” is one phrase that stuck out to me yesterday.
@mad_sters doing critical work in this area for direct care workers
But I think about it for others who work in our system too.
@mad_sters doing critical work in this area for direct care workers
But I think about it for others who work in our system too.
B12 is an important water-soluble organic compound that plays a critical role in the health of our brains. It is involved in DNA synthesis, methylation, and cellular metabolism, which means it is necessary for the proper functioning of our cells. (1/21)
B12 deficiency is a major concern, as it can lead to megaloblastic anemia and neurological problems. But did you know that inadequate #B12 or subclinical deficiency is also very common? (2/21)
It's seen at all ages but definitely in elderly populations. This can be particularly worrisome for those with Alzheimer's disease (AD), as several studies have shown an association between B12 deficiency and #AD. (3/21)
🚨🚨 60 consecutive weeks of Excess non-covid deaths in Scotland 🏴
1,259 deaths registered in Week 16, which is 156 (14%) above 5-year average
47 deaths attributed to ‘COVID’
What is causing these #ExcessDeaths Humza Yousaf, Nicola Sturgeon ??
Is it the jags ??
1/
1,259 deaths registered in Week 16, which is 156 (14%) above 5-year average
47 deaths attributed to ‘COVID’
What is causing these #ExcessDeaths Humza Yousaf, Nicola Sturgeon ??
Is it the jags ??
1/
🔸7,000 excess deaths in the last year🏴
🔸5,000 excess non-covid deaths in the last year
🔸 2,253 excess deaths in 2023 already
🔷 only 699 of the 2,253 excess deaths in 2023 attributed to ‘COVID’ (31%)
🔸 60 consecutive weeks of non-covid excess deaths
Caused by ??
2/
🔸5,000 excess non-covid deaths in the last year
🔸 2,253 excess deaths in 2023 already
🔷 only 699 of the 2,253 excess deaths in 2023 attributed to ‘COVID’ (31%)
🔸 60 consecutive weeks of non-covid excess deaths
Caused by ??
2/
Excess deaths by cause
Scotland, 2023 🏴
#Other 🤷🏻♂️
1,002 excess deaths
#Circulatory 💔
486 excess deaths
#Respiratory
446 excess deaths
#Dementia
219 excess deaths
#Cancer
208 excess deaths
#Covid attributed
699 deaths
The excess death pandemic NOT Covid driven
Scotland, 2023 🏴
#Other 🤷🏻♂️
1,002 excess deaths
#Circulatory 💔
486 excess deaths
#Respiratory
446 excess deaths
#Dementia
219 excess deaths
#Cancer
208 excess deaths
#Covid attributed
699 deaths
The excess death pandemic NOT Covid driven
One in five people suffer from hearing loss
1. Yes, you heard it right.
This information was obtained by a study published in The Lancet journal in Mar 2021.
An estimated 1·57 billion people globally had hearing loss in 2019.
doi.org/10.1016/S0140-…
#MedTwitter
1. Yes, you heard it right.
This information was obtained by a study published in The Lancet journal in Mar 2021.
An estimated 1·57 billion people globally had hearing loss in 2019.
doi.org/10.1016/S0140-…
#MedTwitter
2. Although hearing loss is common in old ages, globally 70 million children aged 0–15 years also live with this condition. Otitis media and meningitis are risk factors for hearing loss in children.
38% of people with hearing loss were less than 50 years old.
#HearingLoss
38% of people with hearing loss were less than 50 years old.
#HearingLoss
3. When unaddressed, childhood hearing loss can affect spoken language development, literacy skills, and education, which might affect cognition and social wellbeing.
Older people with hearing loss have a higher risk of developing #dementia, including #AlzheimersDisease.
Older people with hearing loss have a higher risk of developing #dementia, including #AlzheimersDisease.
People with #dementia have protein build-up in astrocytes that may trigger abnormal antiviral activity and memory loss. Abnormal immune activity in non-neuronal brain cells called astrocytes is sufficient to cause cognitive deficits in dementia.
#2. The discovery could lead to new treatments that reduce excess immune activity in astrocytes and their detrimental effects on other brain cells and cognition.
#3. To understand the causes of memory loss at the molecular level, analyzed gene expression and found high levels of antiviral gene activities, even though no virus was present in the brain. Astrocytes produced excessive amounts of immune messengers called chemokines, which
The largest underlying cause of recent non-COVID-19 excess deaths in Scotland has been “Other causes”
The “Other causes” category also includes deaths which
have an unascertained cause whilst being investigated by the Procurator Fiscal
From Humza Yousaf, Health Secretary
The “Other causes” category also includes deaths which
have an unascertained cause whilst being investigated by the Procurator Fiscal
From Humza Yousaf, Health Secretary
Friend of mine wrote to his MP raising concerns with the high levels of #ExcessDeath in #Scotland🏴
MP then wrote to the then Health Secretary whom provided the response attached
We know where the excess deaths are, but they still won’t face what it is that’s causing the excess
MP then wrote to the then Health Secretary whom provided the response attached
We know where the excess deaths are, but they still won’t face what it is that’s causing the excess
1,520 excess deaths do far in 2023 (week 1-11)
#Cancer
+195
+6%
#Circulatory
+353
+10%
#Dementia
+156
+10%
#Other (ill defined condition)
+688
+21%
‘Covid’ attributed to around 350 of those deaths
Source: #NRS
#Cancer
+195
+6%
#Circulatory
+353
+10%
#Dementia
+156
+10%
#Other (ill defined condition)
+688
+21%
‘Covid’ attributed to around 350 of those deaths
Source: #NRS
Why do we need seniors to have access to a ketogenic diet to help ward off dementia? Because telling them to eat more fish and blueberries is woefully insufficient! Think I am making this up? I am not. It's time for a thread on a recent study. 🧵 (1/19)
The objective of this study was to examine the relationship between consumption frequency of meat, fish, fruits, and vegetables and long-term risk of dementia and Alzheimer’s disease while taking into account the possibility of protopathic bias (i.e., reverse causation). (2/19)
The researchers analyzed data from the Three-city study, which followed 5,934 volunteers aged 65 and over for 12 years. (3/19)
Perceived stress increases the risk of cognitive decline and dementia
1. A recent study looked at the association of perceived stress and incidence of cognitive impairment in a long-term follow up study
jamanetwork.com/journals/jaman…
1. A recent study looked at the association of perceived stress and incidence of cognitive impairment in a long-term follow up study
jamanetwork.com/journals/jaman…
2. 24,448 people (median age 64 years) were followed up for >15 years. Elevated levels of perceived stress (dichotomized as low stress vs elevated stress) was associated with 1.37 times higher odds of poor cognition.
3. The association of the change in the Perceived Stress Scale score with incident cognitive impairment was significant in both the unadjusted model (OR, 1.62) and after adjustment for sociodemographic variables, cardiovascular risk factors, and depression (AOR, 1.39).
#dementia
#dementia
1/To call it or not to call it? That is the question!
Do you feel a bit wacky & wobbly when it comes to calling normal pressure hydrocephalus on imaging?
Here’s a #tweetorial about imaging NPH!
#medtwitter #meded #neurotwitter #neurorad #radres #dementia #neurosurgery #FOAMed
Do you feel a bit wacky & wobbly when it comes to calling normal pressure hydrocephalus on imaging?
Here’s a #tweetorial about imaging NPH!
#medtwitter #meded #neurotwitter #neurorad #radres #dementia #neurosurgery #FOAMed
2/First, you must understand the pathophysiology of “idiopathic” or iNPH. It was first described in 1965—but, of the original six in the 1965 cohort, 4 were found to have underlying causes for hydrocephalus.
This begs the question—when do you stop looking & call it idiopathic?
This begs the question—when do you stop looking & call it idiopathic?
3/Thus, some don’t believe true idiopathic NPH exists. After all, it’s a syndrome defined essentially only by response to a treatment w/o ever a placebo-controlled trial.
However, most believe iNPH does exist--but its underlying etiology is controversial. Several theories exist
However, most believe iNPH does exist--but its underlying etiology is controversial. Several theories exist
Excess death in #England 🏴
🟧 50,000 excess deaths in England over the past 52 weeks
🟣4.2 Million doses of ‘Spring Booster’ given to over 75s
🟢 15.2 Million doses of ‘Autumn Booster’ given to over 50s
Followed by spikes in #ExcessDeaths
Does correlation = causation ?
1/
🟧 50,000 excess deaths in England over the past 52 weeks
🟣4.2 Million doses of ‘Spring Booster’ given to over 75s
🟢 15.2 Million doses of ‘Autumn Booster’ given to over 50s
Followed by spikes in #ExcessDeaths
Does correlation = causation ?
1/
Since the roll out of the first #COVID19 booster in September 2021, there has been 50,000 deaths attributed to ‘Covid’
6,000 #Unvaccinated
44,000 #Vaccinated
30,000 #Boosted
53 Million boosters - and STILL we had 44,000 Covid deaths in the vaccinated!
I see correlation
2/
6,000 #Unvaccinated
44,000 #Vaccinated
30,000 #Boosted
53 Million boosters - and STILL we had 44,000 Covid deaths in the vaccinated!
I see correlation
2/
In January 2023, England suffered 6,632 excess deaths (+12% above average)
#Dementia
+1,219
+17.4%
#HeartFailure
+380
+46.9%
#IschaemicHeartDisease
+394
+7.3%
#Other (Ill defined conditions)
+816
+58.2%
#COVID19
2,106
Note the increase in cardiac deaths & ‘Other’
4/
#Dementia
+1,219
+17.4%
#HeartFailure
+380
+46.9%
#IschaemicHeartDisease
+394
+7.3%
#Other (Ill defined conditions)
+816
+58.2%
#COVID19
2,106
Note the increase in cardiac deaths & ‘Other’
4/
