Discover and read the best of Twitter Threads about #DVT
Most recents (24)
【LSD终极指南：最有潜力的LSD项目】
#上海升级 以来，#LSD 在以太坊爆炸式增长，且可能在其他 L1 网络中继续爆发，引领启动 #DeFi 的强劲反弹，带来LSD Summer🚀
未来哪个LSD会实现十倍，百倍?
本篇深度研究 LSD赛道中最有潜力的项目，无论投资还是质押，都一定能帮你找到 #财富密码 👇
#Crypto
#上海升级 以来，#LSD 在以太坊爆炸式增长，且可能在其他 L1 网络中继续爆发，引领启动 #DeFi 的强劲反弹，带来LSD Summer🚀
未来哪个LSD会实现十倍，百倍?
本篇深度研究 LSD赛道中最有潜力的项目，无论投资还是质押，都一定能帮你找到 #财富密码 👇
#Crypto
📠写在前面：
之前的的文章全面分析了 #板块轮动，强烈建议大家读读。
因上篇thread篇幅受限，没放各板块更全面的分析。但实际上这至关重要，所以才有了这篇关于LSD赛道的全面分析，后续会持续更新其他赛道。
码字不易，如果对你有帮助，请点赞转发。
之前的的文章全面分析了 #板块轮动，强烈建议大家读读。
因上篇thread篇幅受限，没放各板块更全面的分析。但实际上这至关重要，所以才有了这篇关于LSD赛道的全面分析，后续会持续更新其他赛道。
码字不易，如果对你有帮助，请点赞转发。
1/ One item highlighted in @VitalikButerin's Ethereum roadmap is Distributed Validator.
What is 𝗗𝗶𝘀𝘁𝗿𝗶𝗯𝘂𝘁𝗲𝗱 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗼𝗿 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 (#DVT) and could it be the next big narrative for Ethereum after Shapella Upgrade?
🧵 A thread
What is 𝗗𝗶𝘀𝘁𝗿𝗶𝗯𝘂𝘁𝗲𝗱 𝗩𝗮𝗹𝗶𝗱𝗮𝘁𝗼𝗿 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 (#DVT) and could it be the next big narrative for Ethereum after Shapella Upgrade?
🧵 A thread
2/Since Ethereum’s Merge, we have witnessed the Liquid Staking Derivative protocols like @LidoFinance @Rocket_Pool @fraxfinance flourish.
The rapid expansion of the liquid staking, however, has led to concerns about concentration.
The rapid expansion of the liquid staking, however, has led to concerns about concentration.
3/ For instance, @LidoFinance and @coinbase collectively control 90% of the $ETH liquid staking market (Lido alone claims 75% of the market).
It is said that Distributed Validator Technology, or #DVT, could reshape @ethereum Liquid Staking. Why?
写了篇SSV的小文章，分享下：
项目愿景：去中心化的基础设施，解决以太坊2.0质押分布式密钥问题，做以太坊Layer0的基础层，让以太坊更去中心化、安全和抗审核。
项目愿景：去中心化的基础设施，解决以太坊2.0质押分布式密钥问题，做以太坊Layer0的基础层，让以太坊更去中心化、安全和抗审核。
这是以太坊2.0的开发路线图，以太坊2.0是多线程并行，在2022年9月进行合并后，就会发现下一个很重要的阶段就是要做DVT，SSV就是从以太坊基金会研究员手里接过这个外包，从2021年10月份开始开发。
但是SSV团队没有割韭菜，本来可以再发个新币融资，其实没有，就是用老项目的CDT，100CDT比1进行兑换。另外进行了两轮融资，一轮的6刀成本，二轮的12刀成本，主要投的机构是DCG，Coinbas，Lukka，还有各种交易所。
As a #medicine resident you'll come across 👇🏻 scenario often.
Your #surgery colleagues want you to opine on the type and duration of ANTICOAGULATION and also want to know why it occured in the first place🤷♂️
Let's dig deeper 👇🏻
1/24
#MedTwitter #DVT
Your #surgery colleagues want you to opine on the type and duration of ANTICOAGULATION and also want to know why it occured in the first place🤷♂️
Let's dig deeper 👇🏻
1/24
#MedTwitter #DVT
Yeah, this is obviously a Deep Vein Thrombosis (DVT) !
It's fairly common, develops in about 1/1000 people 😮
Remember, DVT+PE = VTE
PE= pulm embolism
VTE= venous thromboembolism
⭐1/3 DVT develop PE⭐
The PE is what can lead to mortality!
Preventing PE is IMPORTANT 🙏🏻
2/24
It's fairly common, develops in about 1/1000 people 😮
Remember, DVT+PE = VTE
PE= pulm embolism
VTE= venous thromboembolism
⭐1/3 DVT develop PE⭐
The PE is what can lead to mortality!
Preventing PE is IMPORTANT 🙏🏻
2/24
DVT is not less of a monster !
Many w/ DVT will develop post thrombotic syndrome 😮 That's a lot of morbidity, leg pain, swelling, ulceration and all 😭
But
🔸Why does VTE occur ?
🔸Who's at risk of developing it ?
🔸Can we prevent it ?
🔸How does one treat it ?
3/24
Many w/ DVT will develop post thrombotic syndrome 😮 That's a lot of morbidity, leg pain, swelling, ulceration and all 😭
But
🔸Why does VTE occur ?
🔸Who's at risk of developing it ?
🔸Can we prevent it ?
🔸How does one treat it ?
3/24
@bhwords Dr. Beverley Hunt presenting on #COVID19 and #thrombosis. She wants to chronologically review the battles we have fought! #ASH22 1/n
🔥We will have a 1 year, and one of its kind Thrombosis Fellowship training program @ccfvascmed starting July 1, 2023. Our highly-acclaimed expert in thrombosis Dr. Marcelo Gomes is the PD. Applicants should be qualified in Vascular Medicine 🫀, hematology 🩸 or IM.
Training will be given by vascular internists, hematologist, cardiologists, clinical pathologists in thrombosis. Real mentorship & protected time for thrombosis research will also be given by @nih_nhlbi funded investigators . Thank you to @InariMedical for sponsorship !
This is a joint venture between @CleClinicHVTI @CCLRI #CleClinicCancer. Formal application available soon. Please DM me if interested. Please retweet. Our staff: my.clevelandclinic.org/departments/he….
1/ For the fellows and #ACCEarlyCareer!
It’s a coronary thrombus! When to consider thrombectomy? What do you do? Let’s walk through this…#Tweetorial
#Cardiotwitter #Cardiology #STEMI
It’s a coronary thrombus! When to consider thrombectomy? What do you do? Let’s walk through this…#Tweetorial
#Cardiotwitter #Cardiology #STEMI
2/ Middle age patient with hx of CAD and PCI to LAD presents with significant SOB and elevated Hs-Trop. No chest pain. No ECG changes. Echo with inferior hypokinesis.
Here’s the diagnostic with a JR4.
Notice the filling defect in the RCA. This is thrombus. How do we know?
Here’s the diagnostic with a JR4.
Notice the filling defect in the RCA. This is thrombus. How do we know?
3/ Keys of #thrombus on angiogram
🔑 contrast staining
🔑 Lack of calcium on non con image
🔑 ovoid filling defect (complete lumen)
#Cardiotwitter #STEMI #TIMI
🔑 contrast staining
🔑 Lack of calcium on non con image
🔑 ovoid filling defect (complete lumen)
#Cardiotwitter #STEMI #TIMI
It took my legs a few minutes to warm up this morning, but glad to report that long morning walks remain easy, in contrast to later in the day. #Totnes is waking up beautifully ☀️
5 miles walked this morning, with no adverse effects. Then strimmed & mowed a lawn. Great to not be worried about my heart and lungs as I got a real workout from the gardening. However, I'm mindful of the warnings of some with #LongCovid that I should continue to pace myself.
Stepping into the first fully post-merge month got us reminiscing about all the special moments that took place in September.
Here’s our quick recap so we can soak it in one last time 👇
🧵1/15
Here’s our quick recap so we can soak it in one last time 👇
🧵1/15
1) Welcome to a new #accredited #tweetorial about an important complication of #pulmonaryembolism (#PE): chronic thromboembolic pulmonary hypertension #CTEPH. Follow this thread to earn 0.75h CE/#CME #physicians #physicianassociates #NPs #nurses #pharmacists.
2) I am Jason Weatherald @AlbertaPHdoc of @UAlberta and you may recall my previous tweetorial in this feed. It's still available for credit at cardiometabolic-ce.com/pah2/. @cardiomet_CE is your ONLY home for earning CE/#CME entirely on Twitter! Howdy to @vic_tapson @lauralynndonah1
3) This program is intended for #healthcare providers and is supported by educational grants from Actelion, Bayer, Chiesi, & AstraZeneca. Faculty disclosures are listed at cardiometabolic-ce.com/disclosures/. Prior programs, still available for credit, are at cardiometabolic-ce.com
1) Welcome to a new #accredited #tweetorial on a🗝️ topic in #cancer care & #vascular medicine: #VTE (#DVT and #PE). Cancer patients are at⬆️risk from their disease, their comorbidities, & often from their treatment. It's a sticky wicket & @cardiomet_CE is proud to welcome ...
2) ... one of the world's leading authorities on cancer-associated VTE as new faculty both here and on @onc_ce: Dr. Alok Khorana @aakonc of @ClevelandClinic, to talk about advances and best treatment in this space!
3) This educational program is intended for health care providers & is supported by a grant from Bristol Myers Squibb & its Alliance partner Pfizer, Inc. Faculty disclosures are listed at cardiometabolic-ce.com/disclosures/. Earn CE/#CME credit from prior programs at cardiometabolic-ce.com.
Don’t miss a new accredited #tweetorial launching TOMORROW here on @cardiomet_CE. #Emergencymedicine #thrombosis researcher @md_pollack will be discussing safe, effective management of selected patients with venous thromboembolism (#VTE) from the #emergencydepartment.
It used to be SOOO much more complicated, but since we entered the era of the #DOACs, #lifeisgood! #Physicians #nurses #pharamcists all work together to make it happen, and all can earn CE/#CME here! @AlexSpyropoul @ScottKaatz @RenatoDLopes1 @GenoMerli @aakonc @vic_tapson
1) Welcome to a #tweetorial on the safe and effective management of acute venous #thromboembolism (#VTE) directly from the #emergencydepartment. This program is accredited for 0.50 credits for #physicians #nurses #pharmacists by @academiccme! I am @md_pollack.
World class @ClevelandClinic Hospital Medicine Grand Rounds - Update in #HospitalMedicine by Dr. Jessica Donato! A rising star! @BIDMC_IM @HarvardHospMed @CWRUSOM @SocietyHospMed
Is postop #afib associated w increased risk for CVA/TIA?
1/ #Tweetorial Part 2- Now its time to talk about….
CHRONIC
C-L-O-T
#VTE #DVT #Thrombectomy #Lytics #Cardiotwitter #IRAD #Medthread #Clot @CardioBot @RadialFirstBot @BotPci @EPeeps_Bot @TAVRBot @MedTweetorials @UjjwalRastogiMD @Umair2017 @Umair2017 @VenuVadlamudiMD
CHRONIC
C-L-O-T
#VTE #DVT #Thrombectomy #Lytics #Cardiotwitter #IRAD #Medthread #Clot @CardioBot @RadialFirstBot @BotPci @EPeeps_Bot @TAVRBot @MedTweetorials @UjjwalRastogiMD @Umair2017 @Umair2017 @VenuVadlamudiMD
2/ How much time does it take for #ChronicClot to START to form?
#Fellowstwitter #fellows #fellowtwitter #medtwitter #Clottwitter #VTE @MedTweetorials @CardioBot #Tweetorial #Meded @GAEscobarMD @ekgpdx @HeartOTXHeartMD @EM_RESUS @Pooh_Velagapudi @Vascupedia_com @Dr_Bowser
#Fellowstwitter #fellows #fellowtwitter #medtwitter #Clottwitter #VTE @MedTweetorials @CardioBot #Tweetorial #Meded @GAEscobarMD @ekgpdx @HeartOTXHeartMD @EM_RESUS @Pooh_Velagapudi @Vascupedia_com @Dr_Bowser
Pulmonary #embolism (lung blood clot) was >10 times more common after #SARSCoV2 infection (COVID19; ~15x over background rate), vs after getting #Pfizer's or #AstraZeneca's vaccine (~1.2x> background)
Similar greater risks with COVID-19 for #DVT & #VTE
🧵
medrxiv.org/content/10.110…
Similar greater risks with COVID-19 for #DVT & #VTE
🧵
medrxiv.org/content/10.110…
2) First of all – as the authors note – in those #vaccinated against COVID-19, "thrombosis, thrombocytopenia, and thrombosis with thrombocytopenia were very rare events."
3) Data from 1.9 Million (M) recipients of AstraZeneca, ~1.7 M of Pfizer, and ~300k COVID-19 cases (few old) – compared with ~2.3 M in the general population.
These cohorts were used to calculate the observed incidence vs. background (SIR) or observed vs. expected # of cases.
These cohorts were used to calculate the observed incidence vs. background (SIR) or observed vs. expected # of cases.
1/ Welcome to the first part of a #Tweetorial series on #VenousDisease.
🩸To begin how about we talk about the main player in the game- C.L.O.T. (and why you should care about it)
#Cardiotwitter #Irad #fellows #fellowtwitter #medthread #clot #medtwitter #clottwitter
🩸To begin how about we talk about the main player in the game- C.L.O.T. (and why you should care about it)
#Cardiotwitter #Irad #fellows #fellowtwitter #medthread #clot #medtwitter #clottwitter
2/ But first a question- Is there a difference between arterial and venous clot??
#Clot #cardiology #DVT #irad #VenousDisease #medthread #tweetorial #fellows @HadyLichaaMD @VladLakhter @agtruesdell @AntoniousAttall @TheNarulaSeries @t_intheleadcoat @ShariqShamimMD
#Clot #cardiology #DVT #irad #VenousDisease #medthread #tweetorial #fellows @HadyLichaaMD @VladLakhter @agtruesdell @AntoniousAttall @TheNarulaSeries @t_intheleadcoat @ShariqShamimMD
3/ All clots ARE NOT born equally! There is a difference!
THREAD:5⃣things to know from 5 recent TI Therapeutics Letters👩🏽🔬
1/5: How to choose a good #mirtazapine dose? 🤔
Mirtazapine has a dose response 💊for harm but NOT for efficacy: harm ↗️ after 30mg/day but efficacy doesn't: bit.ly/361LU9E
#MedEd #deprescribing #ptsafety
1/5: How to choose a good #mirtazapine dose? 🤔
Mirtazapine has a dose response 💊for harm but NOT for efficacy: harm ↗️ after 30mg/day but efficacy doesn't: bit.ly/361LU9E
#MedEd #deprescribing #ptsafety
2/5: Want to learn about recent @GovCanHealth #medsafety or international warnings for medications?
Read our Therapeutics Letter on international drug safety advisories: bit.ly/3wc0ar8 ⚠️ 💊
#drugsafety #SegPac #ptsafety
Read our Therapeutics Letter on international drug safety advisories: bit.ly/3wc0ar8 ⚠️ 💊
#drugsafety #SegPac #ptsafety
3/5: Do you like receiving feedback on your #prescribing?👩🏽⚕️💊
Read about Personal Prescribing Portraits: bit.ly/3hkf8WO
#MedEd #deprescribing
Read about Personal Prescribing Portraits: bit.ly/3hkf8WO
#MedEd #deprescribing
🧵 “How can I improve #PICC safety in my hospital?”
I’ve received many questions like this following the recent publication of our @BMJ_Qual_Saf paper showing how we did this in 50+ hospitals.
qualitysafety.bmj.com/content/early/…
Today, we released the formula (Thread)
I’ve received many questions like this following the recent publication of our @BMJ_Qual_Saf paper showing how we did this in 50+ hospitals.
qualitysafety.bmj.com/content/early/…
Today, we released the formula (Thread)
@BMJ_Qual_Saf First, head over to improvePICC.com and click on “Implementation” in the top menu - this will take you to the Roadmap for Quality Improvement.
@BMJ_Qual_Saf Then, pause for a moment.
You’re about to go on a journey - a #qualityimprovement journey.
Look for your markers, prepare yourself for change!
You’re about to go on a journey - a #qualityimprovement journey.
Look for your markers, prepare yourself for change!
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
1/20
New in @ATSBlueEditor, the culmination of over 4 years of work in the @bradleymaron lab, in which we identify that #NEDD9 is a hypoxia-regulated pulmonary endothelial protein that directly binds activated platelets to promote pulmonary thrombosis.
atsjournals.org/doi/10.1164/rc…
New in @ATSBlueEditor, the culmination of over 4 years of work in the @bradleymaron lab, in which we identify that #NEDD9 is a hypoxia-regulated pulmonary endothelial protein that directly binds activated platelets to promote pulmonary thrombosis.
atsjournals.org/doi/10.1164/rc…
2/20
The @bradleymaron lab previously discovered that the malignancy protein #NEDD9 promotes endothelial fibrosis by regulating collagen synthesis in human pulmonary artery endothelial cells (HPAECs), which could be targeted to inhibit #PAH in vivo.
stm.sciencemag.org/content/10/445…
The @bradleymaron lab previously discovered that the malignancy protein #NEDD9 promotes endothelial fibrosis by regulating collagen synthesis in human pulmonary artery endothelial cells (HPAECs), which could be targeted to inhibit #PAH in vivo.
stm.sciencemag.org/content/10/445…
3/20
As a pro-metastatic protein, #NEDD9 interacts with pro-thrombotic cell types, & it was shown to be ⬆️ via #HIF1α in cancer cells to promote migration. We hypothesized that #NEDD9 is ⬆️ by hypoxia in HPAECs ➡️ pathogenic platelet-EC adhesion.
cancerres.aacrjournals.org/content/70/10/…
As a pro-metastatic protein, #NEDD9 interacts with pro-thrombotic cell types, & it was shown to be ⬆️ via #HIF1α in cancer cells to promote migration. We hypothesized that #NEDD9 is ⬆️ by hypoxia in HPAECs ➡️ pathogenic platelet-EC adhesion.
cancerres.aacrjournals.org/content/70/10/…
Here is the #PedsICU #BestOf2020 collection.
Jointly chosen by
@Dr_Hari_Krishna @sgdambrauskas and myself
Pubmed collection 40 articles: bit.ly/pedsicubestof2…
Infographic (clickable PDF) in English: bit.ly/bestof2020eng
Spanish: bit.ly/bestof2020esp
#PedsCICU #NeuroPICU
Jointly chosen by
@Dr_Hari_Krishna @sgdambrauskas and myself
Pubmed collection 40 articles: bit.ly/pedsicubestof2…
Infographic (clickable PDF) in English: bit.ly/bestof2020eng
Spanish: bit.ly/bestof2020esp
#PedsCICU #NeuroPICU
This will be a bilingual tweetorial in Spanish/English!
Infographics are available in both languages in Tweet #1
El hilo será en Español/Inglés. El resumen infográfico está disponible en los dos idiomas en el primer Tweet
Infographics are available in both languages in Tweet #1
El hilo será en Español/Inglés. El resumen infográfico está disponible en los dos idiomas en el primer Tweet
1/What are the outcomes that matter to children, to families and to #researchers/clinicians? @ericka_fink et al & @PostPICU_PALISI investigators identified COS using a delphi process. @CritCareMed bit.ly/381cfq8. Developmental and functional outcomes were important.
Kicking off multidisciplinary Research Consensus Panel (RCP) to finally investigate the ❓: what is the optimal medical therapy (OMT) following venous recan? Follow #VenousRCP throughout the day to learn more and contribute! #SIRFoundation @SIRRFS @SIR_ECS @JVIRmedia
🔴 Pathophysiology of venous thromboembolism #VTE
🟠Venous recanalization & stenting
🟡The mystery of medical therapy following recanalization
🟢Patency & outcome measures
🔵Economics & cost-effectiveness of treatment
🟣Future directions
#VenousRCP
🟠Venous recanalization & stenting
🟡The mystery of medical therapy following recanalization
🟢Patency & outcome measures
🔵Economics & cost-effectiveness of treatment
🟣Future directions
#VenousRCP
🔴 ✅#VTE affects ~100 of every 100,000 people yearly in the US
✅Incidence of VTE ⬆️⬆️ exponentially with age, especially after 40
✅#Endovascular recan is a common tx; post-tx algorithms vary widely
✅More #epidemiology info @CircAHA bit.ly/37IptZh
@Pertconsortium
✅Incidence of VTE ⬆️⬆️ exponentially with age, especially after 40
✅#Endovascular recan is a common tx; post-tx algorithms vary widely
✅More #epidemiology info @CircAHA bit.ly/37IptZh
@Pertconsortium
