Discover and read the best of Twitter Threads about #Darunavir

Most recents (3)

1/ Little Thread about all The Misleading Medical Information still floating around about #Hydroxychloroquine & #Chloroquine & #Azithromycin & #ZelenkoProtocol - by 1 doctor - @zev_dr & #Remdesivir & more

Despite #TrumpIsNotADoctor has stopped saying "What do you have to lose?".
2/ #TrumpIsTheWORSTPresidentEVER

First, why it has been political all the way, suspected from day one:

"Trump had been touting HCQ for weeks, sparking worldwide shortages of HCQ & prompting negotiations with Indian PM Modi to lift export restrictions"

vanityfair.com/news/2020/04/i…
3/ #Trump2020

Indian PM Modi and Trump held a rally together.

"Mr Trump wanted to show people in the US that he was hugely popular abroad and that he was capable of negotiating good deals out of a country he once described as the king of tariffs"

bbc.com/news/world-sou…
Read 45 tweets
There is no proven effective antiviral drug for the treatment of #SARSCoV2

Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...
1/
#Chloroquine
Anti-malaria

Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins

#chloroquine and #redemsivir are active against SARS-COV2 in experimental models

doi.org/10.1038/s41422…
2/
#Hydroxychloroquine
- Analogue of chloroquine
- Anti inflammatory effect

Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.

doi.org/10.1093/cid/ci…
Read 17 tweets
#China state TV flagged that researchers at Zhejiang Univ found 2 drugs #arbidol & #darunavir inhibit #coronavirus. Lead scientist is recommending the drugs be included in National Health Commission’s official protocol. Commission cautions so far no confirmed effective treatment.
#China National Health Commission revised its protocol for #WuhanCoronavirus. It is now:

-alpha-interferon (inhalation)
-lopinavir/ritonavir (2 pills twice a day)
-ribavirin (optional, 4g first time, followed by 1.2g every 8 hours)
#China health officials much more focused on anti-viral drug #remdesivir by @GileadSciences. State media report phase III clinical trials of remdesivir started this PM in #Wuhan, virus hot zone.
Read 4 tweets

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