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Lots of questions about the role of serologic testing for #COVID19 over the past few days.
So, my $0.02:
1. We do not diagnose other respiratory infections w/ serology...#SARSCoV2 is no different.
So, my $0.02:
1. We do not diagnose other respiratory infections w/ serology...#SARSCoV2 is no different.
2. Initial studies from China suggest seroconversion occurs in most pts around Day 11 (preprint below).
What this means is that serology is:
✔️#NotHelpful for Dx of acute/symptomatic infection.
✔️#DefinitelNotHelpful at the POC! 😱🤯
medrxiv.org/content/10.110…
What this means is that serology is:
✔️#NotHelpful for Dx of acute/symptomatic infection.
✔️#DefinitelNotHelpful at the POC! 😱🤯
medrxiv.org/content/10.110…
Regarding specificity, although there are some epitope differences by crystal stx between the spike protein of #SARSCov2 and other coronaviruses, we really do not know ANYTHING about the specificity of these COVID19 ELISAs yet.
Hopefully we’ll have some data soon
Hopefully we’ll have some data soon
