Discover and read the best of Twitter Threads about #Denosumab
Most recents (4)
As the year ends, it's time once again to discuss some of the best clinical papers in the 🦴 #bone field in 2022!
A long 🧵
@Sandroppa @ECTS_science @larsfolkestad
A long 🧵
@Sandroppa @ECTS_science @larsfolkestad
Nr. 1: Supplemental #VitaminD and Incident #Fractures in Midlife and Older Adults @NEJM
No effect in the VITAL trial although confidence intervals do not exclude meaningful reduction in patients on osteoporosis meds or with fracture history
nejm.org/doi/full/10.10…
No effect in the VITAL trial although confidence intervals do not exclude meaningful reduction in patients on osteoporosis meds or with fracture history
nejm.org/doi/full/10.10…
#VitaminD Deficiency Increases Mortality Risk in the UK Biobank
A Nonlinear Mendelian Randomization Study
Risk increased steeply < 50 nmol/L and was greater with genetic than phenotypic vitamin D deficiency
@AnnalsofIM
acpjournals.org/doi/10.7326/M2…
A Nonlinear Mendelian Randomization Study
Risk increased steeply < 50 nmol/L and was greater with genetic than phenotypic vitamin D deficiency
@AnnalsofIM
acpjournals.org/doi/10.7326/M2…
With 2020 almost over, it's time again to look back at some of the BEST in the #bone field: 🔝20 papers (+extras).
Happy to hear your input! Disclosure: fully subjective ranking!
@ASBMR @AcademyEcts @Osteoporosis_NL @osteoporosisNI @mmse30 @NatalieASims
Happy to hear your input! Disclosure: fully subjective ranking!
@ASBMR @AcademyEcts @Osteoporosis_NL @osteoporosisNI @mmse30 @NatalieASims
#1 Atypical Femoral fractures @NEJM (Black DM et al.)
Risk reduces within months of @Bisphosphonate1 discontinuation. Benefit>risk in any group but less so in Asians and women <65yr
nejm.org/doi/10.1056/NE…
Risk reduces within months of @Bisphosphonate1 discontinuation. Benefit>risk in any group but less so in Asians and women <65yr
nejm.org/doi/10.1056/NE…
-side note- @ECTS_science very useful systematic review and recommendations for managing osteoporosis following AFFs.
ncbi.nlm.nih.gov/pmc/articles/P…
And oral BPs may not only reduce fractures but also cardiovascular events
pubmed.ncbi.nlm.nih.gov/32717068/
@Dr_BoAbrahamsen @prieto_alhambra
ncbi.nlm.nih.gov/pmc/articles/P…
And oral BPs may not only reduce fractures but also cardiovascular events
pubmed.ncbi.nlm.nih.gov/32717068/
@Dr_BoAbrahamsen @prieto_alhambra
اليوم موضوعنا من اشهر واهم مواضيع العظام 😍اللي هو
#Osteoporosis
#هشاشةالعظام
تعالوا نشوف تفاصيل المرض في هذا الثريد 👇🏼
#Osteoporosis
#هشاشةالعظام
تعالوا نشوف تفاصيل المرض في هذا الثريد 👇🏼
ايش يعني هشاشة عظام ؟ Osteoporosis
is a bone disorder characterized by low bone density, impaired bone
architecture, and compromised bone strength predisposing to fracture.
is a bone disorder characterized by low bone density, impaired bone
architecture, and compromised bone strength predisposing to fracture.
Pathophysiology
Two cells are responsible for promoting bones health:
⭕️osteoblast (promotes the
formation of bone tissues) خلايا بناءة
⭕️osteoclast (promotes bone breakdown) خلايا هادمة
Osteoporosis occurs when the resorption (bone breakdown) exceeds the formation.
Two cells are responsible for promoting bones health:
⭕️osteoblast (promotes the
formation of bone tissues) خلايا بناءة
⭕️osteoclast (promotes bone breakdown) خلايا هادمة
Osteoporosis occurs when the resorption (bone breakdown) exceeds the formation.
#COVIDー19
#Osteoporosis
Está bien claro que nuestros mayores no solo son más vulnerables frente al #Covid_19 sino que además lo son frente a la osteoporosis que se agravó con el #confinamiento
#hilo Revisión
⬇️⬇️ sci-hub.im/downloads-ii/2…
#Osteoporosis
Está bien claro que nuestros mayores no solo son más vulnerables frente al #Covid_19 sino que además lo son frente a la osteoporosis que se agravó con el #confinamiento
#hilo Revisión
⬇️⬇️ sci-hub.im/downloads-ii/2…
1️⃣Asesoramiento del riesgo de #fracturas
Va a salir a la calle y su movilidad se ha visto reducida
2️⃣ Los pacientes que reciben
bisfosfonatos intravenosos pueden tener reacciones flu-like. Toca hacer diagnóstico diferencial
3️⃣Evitar la interrupción de #denosumab
Va a salir a la calle y su movilidad se ha visto reducida
2️⃣ Los pacientes que reciben
bisfosfonatos intravenosos pueden tener reacciones flu-like. Toca hacer diagnóstico diferencial
3️⃣Evitar la interrupción de #denosumab
4️⃣¿Cambios en el tratamiento?
El cambio de un antirresortivo a un agente osteoanabolizante puede ser complicado ahora
5️⃣ Y POR SUPUESTO, hacer hincapié en el entrenamiento SOBRE TODO DE FUERZA domiciliario
El cambio de un antirresortivo a un agente osteoanabolizante puede ser complicado ahora
5️⃣ Y POR SUPUESTO, hacer hincapié en el entrenamiento SOBRE TODO DE FUERZA domiciliario
