Discover and read the best of Twitter Threads about #Dichotomania
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1/7 #PREPAREII showed that a 500-ml fluid bolus does not prevent cardiovascular collapse during tracheal intubation in the ICU. I love efficient study designs - this trial had two features that in my opinion are worth replicating in future #criticalcare #RCTs (a thread ๐งต):
2/7 Sample size: the authors calculated that 750 patients would be needed to detect a MCID with an 80% power. After a blinded interim analysis it became clear that the event rate is lower than expected. Smart study design feature no.1๏ธโฃ: adaptive sample size re-estimation.
3/7 The goal of sample size re-estimation is to prevent the dreaded "underpowered study" - a situation where the trial can no longer rule out that a clinically meaningful effect exists due to the signal/noise ratio in the data being to low. You can do it using both frequentist &
This month I revisit #COURAGE. The ultimate conversation starter among @JAMAInternalMed readers and interventional cardiologists. #CQOSpotlight
Quick someone tweet a concerning angiogram cine and ask if anyone else would refer a specific stable CAD patient to OMT!!
Quick someone tweet a concerning angiogram cine and ask if anyone else would refer a specific stable CAD patient to OMT!!
๐๐ฎ๐ฐ๐ธ๐ด๐ฟ๐ผ๐๐ป๐ฑ: The #COURAGE investigators provide longer survival follow-up on subset of the original study cohort to evaluate how the number of coronary lesions vs. amount of ischemia is prognostic for patients with stable CAD. ahajournals.org/doi/10.1161/CIโฆ
The subset of patients received both quantitative coronary angiograms (QCA) and stress (SPECT) perfusion imaging.
