Discover and read the best of Twitter Threads about #E406W
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How a single amino acid mutation #E406W mediates escape from the REGN10987/REGN10933 antibody cocktail despite residing outside their epitopes 1/ 
This residue substitution remodels the ACE2-binding site allosterically, thereby dampening receptor recognition severely and altering the epitopes recognized by these mAbs. 2/
mRNA vaccine-elicited neutralizing antibody titers are decreased ~2.5-fold against the E406W mutant, to levels similar to the ones against Delta or Epsilon #SARSCoV2 variants, which is impressive for a single point mutation! 3/
