Discover and read the best of Twitter Threads about #ENECOVID

Most recents (3)

1/ Estimating the infection fatality risk (IFR) of #SARSCoV2 is hard.

Our estimates from Spain's #ENECOVID (just published):
Men: 1.1% to 1.4%
Women: 0.58% to 0.77%

After age 80
Men: 12% to 16%
Women: 4.6% to 6.5%

Why is the #IFR hard to estimate?
bmj.com/content/371/bm…
2/ The IFR in a population is the ratio of

number of deaths from SARS-CoV-2 infection (numerator)

and

number of individuals infected by SARS-CoV-2 (denominator)

during a prespecified period.

Both numerator and denominator are hard to quantify.
3/ Why is the denominator hard to quantify?

The number of infected with #SARSCoV2 is not the number of confirmed #COVID19 cases.

Because many infected individuals never have symptoms or have minor symptoms and are never diagnosed.

(For details, see journals.plos.org/plosntds/artic…)
Read 6 tweets
Y a vueltas de nuevo con el Tocilizumab

nejm.org/doi/full/10.10…
Nice explanation about vaccines efficacy, development and trials by @mlipsitch

Must read 👌
@Virusemergentes @Luis_Corral_Gud
@ligero999 @MariadelMarTom

science.sciencemag.org/content/early/…
No quiero dejar de traer al hilo este ensayo con plasma de convaleciente que me llega a través de @gorka_orive

El ensayo tiene algunas limitaciones pero la evidencia que aporta no debería soslayarse. No son buenas noticias

bmj.com/content/371/bm…
Read 416 tweets
🛑The effect of corticosteroids on patients with Covid19: a SR /MA

➡️Corticost. could lead to ⬆️ mortality, LOS, rate of bacterial infection and hypokalemia. It should be used with caution in covid19; not recommended for patients with mild conditions

journalofinfection.com/article/S0163-… ImageImageImageImage
🛑#SARS-CoV2 and immunosuppression: a double-edged sword

Otra de las grandes incógnitas es la evolución de los pts receptores de transplante ante la #Covid_19

▶️Resumen de evidencias (pocas), y manejo farmacoterapéutico

onlinelibrary.wiley.com/doi/epdf/10.11… Image
Añado al hilo, aporte de @fgilc y comentario de @Luis_Corral_Gud por ser de gran interés.
Interferón y desenlaces clínicos en #Covid_19

Read 417 tweets

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