Discover and read the best of Twitter Threads about #ER_phagy
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!!!NEW!!! A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress #autophagy #ER_phagy #ER_Literature #ufmylation biorxiv.org/content/10.110… a thread 1/8 
Via a screen in Arabidopsis, we identified C53, an #IDR containing highly conserved protein, as a direct #ATG8 interactor. It interacts 8/9 arabidopsis, 1/2 marchantia and 2/6 human ATG8s via the LDS 2/8
Using native mass spec, ITC, SPR and cell biology, we showed that it binds ATG8 via a non-canonical AIM, that we named Shuffled AIM (sAIM)- IDWG 3/8
