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Based on the above images only, what is your first impression?
* of the thyroid
* of the thyroid
Membranous type Basal Cell Adenoma (BCA).
🧨 Morphologically identical to cutaneous cylindroma, hence aka dermal analogue tumor.
🧨 This is a unique morphologic subtype that one should be aware of.
Why? Read below. #ENTpath
#pathology #pathboards #S&L 1/3
🧨 Morphologically identical to cutaneous cylindroma, hence aka dermal analogue tumor.
🧨 This is a unique morphologic subtype that one should be aware of.
Why? Read below. #ENTpath
#pathology #pathboards #S&L 1/3
🧨 Because this particular subtype can be multifocal.
🧨 This can be associated with Brooke Spiegler syndrome, a rare AD disease caused by mutation of CYLD gene on chr 16.
🧨 This has a higher rate of local recurrence (25%) than other subtypes. 2/3
🧨 This can be associated with Brooke Spiegler syndrome, a rare AD disease caused by mutation of CYLD gene on chr 16.
🧨 This has a higher rate of local recurrence (25%) than other subtypes. 2/3
🧨 And this has high propensity for transformation into a basal cell adenocarcinoma.
🔬 Islands of basaloid cells surrounded by eosinophilic hyaline material, jigsaw puzzle like pattern & peripheral palisading.
3/3 #S&L
🔬 Islands of basaloid cells surrounded by eosinophilic hyaline material, jigsaw puzzle like pattern & peripheral palisading.
3/3 #S&L
Beautiful example of a secretory carcinoma of the salivary gland. Secretory carcinoma (aka mammary analogue secretory carcinoma) is a ~recently described malignant tumor of the salivary gland, most commonly the parotid as in this case. Classically presents as a painless mass 1/5
in a middle-aged adult. Histologic appearance can vary significantly from well-circumscribed, lobulated growth with fibrous septa to infiltrative; papillary, solid, follicular and cystic architectures are common. Watch out for excessive solid growth, necrosis, mitotic 2/5
activity and/or significant cytologic atypia in cases of SC with high-grade transformation. Because of the variable histologic findings, IHC can be essential (esp. when presenting outside of the salivary gland): classically S100+ mammaglobin+ GCDFP-15+ SOX-10+ TTF1- AR-. 3/5
Time for another #grossognosis #ENTpath #Pedipath
Tongue lesion in a young kid.
@TheKarenPinto @renemaf @AnnieMcLeanDMD @DrAhmedKalebi @DrRolaAli @merva_st @TheKarenPinto @VijayPatho @doc_kartik @luishcruzc @kis_lorand
Tongue lesion in a young kid.
@TheKarenPinto @renemaf @AnnieMcLeanDMD @DrAhmedKalebi @DrRolaAli @merva_st @TheKarenPinto @VijayPatho @doc_kartik @luishcruzc @kis_lorand
H&E: Sorry @DrAhmedKalebi No pseudoepitheliomatous hyperplasia. @OkelloAliker
Any differential? Any IHC/molecular you would like to have?
I should also mention that the patient is immune compromised.
Any differential? Any IHC/molecular you would like to have?
I should also mention that the patient is immune compromised.
This turns out to be EBV-associated smooth muscle tumor (HE/SMA/EBER). Kudo to @lizawati38
3 spindle cell tumors in immune compromised:
- KS
- EBV-SMT
- microbacterial spindle cell pseudotumor
Without clinical history: ddx broader including all cellular spindle cell lesions.
3 spindle cell tumors in immune compromised:
- KS
- EBV-SMT
- microbacterial spindle cell pseudotumor
Without clinical history: ddx broader including all cellular spindle cell lesions.
A to Z alphabet in #ENTpath #oralpath #endopath
A: angioinvasive fungal sinusitis, adenoid cystic carcinoma, ameloblastic fibroima and anaplastic thyroid carcinoma
@smlungpathguy @aakasharmand @VijayPatho @TheKarenPinto @histolover @Histopatolomon @luishcruzc @kriyer68
A: angioinvasive fungal sinusitis, adenoid cystic carcinoma, ameloblastic fibroima and anaplastic thyroid carcinoma
@smlungpathguy @aakasharmand @VijayPatho @TheKarenPinto @histolover @Histopatolomon @luishcruzc @kriyer68
B
Basal cell adenoma
Biphenotypic sinonasal sarcoma
branchial cleft cyst
Basal cell adenoma
Biphenotypic sinonasal sarcoma
branchial cleft cyst
C
Clear cell carcinoma
Clear cell odontogenic carcinoma
Chordoma
CEOT
Clear cell carcinoma
Clear cell odontogenic carcinoma
Chordoma
CEOT
