Discover and read the best of Twitter Threads about #Epigenome
Most recents (5)
1/5 Fascinating work from Jae-Hyun Yang and colleagues on #mammalian #aging, published in Cell...
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
An abstract thread 🧵...
"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."
cell.com/cell/fulltext/…
2/5 "In #yeast, #epigenetic information is lost over time due to the relocalization of #chromatin-modifying proteins to #DNA breaks, causing cells to lose their identity, a hallmark of yeast #aging."
3/5 "Using a system called “#ICE” (#inducible changes to the #epigenome), we find that the act of faithful #DNA #repair advances aging at #physiological, #cognitive, and #molecular #levels, including #erosion of the #epigenetic #landscape,..."
It’s here! 🎉 Our study reveals both new and known #geneexpression programs involved in hippocampal memory following #adolescent #exercise, and also investigates two #epigenetic regulatory mechanisms (open access @CommsBio) 1/
urldefense.com/v3/__https://r…$
urldefense.com/v3/__https://r…$
We asked which genes are regulated after aerobic exercise (voluntary wheel running) in adolescent #hippocampus using a transgenic mouse & technique we developed for simultaneous sequencing of the #epigenome and translatome in excitatory #neurons. 2/
Using our “SIT”protocol from a single hippocampus (Simultaneous INTACT and TRAP; yes we used “SIT” in running mice!) found high correlation (Spearman’s) when compared to traditional INTACT/TRAP in separate samples. Protocol here: 3/
…rentprotocols.onlinelibrary.wiley.com/doi/full/10.10…
…rentprotocols.onlinelibrary.wiley.com/doi/full/10.10…
Our many-years-in-the-making EpiC Dog epigenome paper is finally out as preprint @biorxivpreprint
Close collaboration with our lab's lead bioinformatician @new__hong & MBD-seq aficionado @MethylAReum, spearheaded by our versatile PI @je_yoel @SNUnow #Epigenome #Genomics #Dog A🧵
Close collaboration with our lab's lead bioinformatician @new__hong & MBD-seq aficionado @MethylAReum, spearheaded by our versatile PI @je_yoel @SNUnow #Epigenome #Genomics #Dog A🧵
While still in early stage format, EpiC Dog is a culmination of our efforts to annotate functional elements of dog genome enabled by chromatin states discovery and profiling super-enhancer and DNA methylome landscapes across multiple tissue types. See also BarkBase and DoGA /2
Modern dogs are champions of modern genetics. They empower us with their evolution and diversification of phenotypic traits from morphology to behavior. One reason dog genomics has become >popular compared to genomic studies of other domesticated mammals, but who's comparing? /3
Daily Bookmarks to GAVNet 07/02/2021 greeneracresvaluenetwork.wordpress.com/2021/07/02/dai…
Cognitive Economics: How Self-Organization and Collective Intelligence Works
evonomics.com/cognitive-econ…
#CognitiveEconomics #SelfOrganization #CollectiveIntelligence #groups
evonomics.com/cognitive-econ…
#CognitiveEconomics #SelfOrganization #CollectiveIntelligence #groups
THE FREEDOM OF THE PRESS
orwellfoundation.com/the-orwell-fou…
#HumanRights #FreedomOfThePress #GeorgeOrwell #AnimalFarm #BookPublishing
orwellfoundation.com/the-orwell-fou…
#HumanRights #FreedomOfThePress #GeorgeOrwell #AnimalFarm #BookPublishing
I wasn’t really expecting this tweet to get such a response. It clearly hit a communal nerve. Probably in part because I was deliberately provocative 1/
2/ Did @ryanlisterlab really show that DNA methylation has no role in transcriptional repression? Of course not. But they do show that it does not seem to be enough by itself to change the expression of genes
3/ Why is that observation important? Because it makes us think a bit more critically about something that plagues #epigenome-wide association studies, the idea that environment changes DNA methylation, gene expression and cellular memory.
