Discover and read the best of Twitter Threads about #Etomidate
Most recents (1)
#Etomidate and mortality in critically ill patients
Etomidate is a common induction agent but controversy exists about its effects on outcomes
Our meta-analysis found a high probability that etomidate increases mortality (NNH 31)
🧵Thread 1/6 🔗sciencedirect.com/science/articl… #FOAMcc
Etomidate is a common induction agent but controversy exists about its effects on outcomes
Our meta-analysis found a high probability that etomidate increases mortality (NNH 31)
🧵Thread 1/6 🔗sciencedirect.com/science/articl… #FOAMcc
2/
PICOS of this SR/MA
P: Critically ill patients
I: #Etomidate as an induction agent for intubation
C: Any comparator
O: Mortality at the main timepoint defined by authors
S: Randomized controlled trials
11 RCTs with 2704 patients were included
#FOAMcc
PICOS of this SR/MA
P: Critically ill patients
I: #Etomidate as an induction agent for intubation
C: Any comparator
O: Mortality at the main timepoint defined by authors
S: Randomized controlled trials
11 RCTs with 2704 patients were included
#FOAMcc
3/
#Etomidate was associated with significantly increased mortality (23% vs 20%; risk ratio = 1.16 [1.01–1.33]; P = 0.03)
The number needed to harm was 31
The probabilities of any increase and a 1% increase (NNH ≤100) in mortality were 98.1% and 92.1%, respectively.
#FOAMcc
#Etomidate was associated with significantly increased mortality (23% vs 20%; risk ratio = 1.16 [1.01–1.33]; P = 0.03)
The number needed to harm was 31
The probabilities of any increase and a 1% increase (NNH ≤100) in mortality were 98.1% and 92.1%, respectively.
#FOAMcc
