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Very excited to share my work on Stag2, chromatin architecture, and effects on hematopoiesis! Join me in a @MedTweetorials of why this is so important! @CellStemCell cell.com/cell-stem-cell…
The cohesin complex is comprised of structural proteins (Smc1a, Smc3, Rad21) bound to a Stag protein. We and others have described that alterations of each affect hematopoietic self-renewal and differentiation.
However, both the mechanism and the biologic reason for the overwhelming prevalence of STAG2 being overwhelmingly the most commonly mutated component in cancer was still not known.
