Discover and read the best of Twitter Threads about #EvidenceBasedMedicine

Most recents (7)

There's buzz about #Glenmark new drug #Favipiravir for #COVID__19
Do we have the data based on which approval was granted? @CDSCO_INDIA_INF
Given the desperate situation, physicians & patients are likely to flock to get this, but do we have some hard outcomes to show it helps?
I tried to find published studies on #Favipiravir but haven't yet found supportive data in the searches I did. Would be grateful if someone could point out the evidence. And I hope it's not a single arm study where x% improved because x% could have improved anyway.
If our standards for other drugs are well conducted randomized trials, let's not lower the bar for #Favipiravir just because someone's marketing it, and we don't have any eligible candidates at hand. #EvidenceBasedMedicine
Read 3 tweets
On a tweet-spree, sharing my 2-cent thoughts after 2 months of #COVID duty work:
🔸️ Different patient, different body response - management algorithm can guide you, but individualized care is a must
🔸️Organ systems works hand-in-hand; Nutrition is just as important as ventilation, circulation, etc
🔸️Management is evolving (in a matter of hours); what you know now might not be applicable tomorrow. Keep yourself updated.
🔸️Giving medications just so we have something to give, can be worse than not giving anything at all. #EvidenceBasedMedicine
🔸️Team work goes a long way - ask HELP, be it clinical dilemna or handy ward work. After all, We're on the same boat🛶
Read 5 tweets
Copied from a friend. I don't know who needs to see this, but #Plandemic is a bunch of BS. For many reasons. Let's stick with science.

#EvidenceBasedMedicine #Covid19
For further further reading:…
Read 6 tweets
The past few days have included a lot of thoughtful debate/discussion about #COVID19 and #ARDS, some snark (of which I too am guilty), and a hefty dose of HOW DARE YOU CHALLENGE A MASTER, YOUR RIGIDITY IS KILLING PEOPLE. I have a few things to say. Bear with me as I ramble a bit.
The idea that #EvidenceBasedMedicine does not allow for individualization for specific patients and changes in their clinical courses is a fallacy. Certain concepts that are known to save lives can & should be adhered to in a manner that is appropriate for the individual patient.
I thought this was obvious but that clearly is not everyone’s interpretation of #EBM. Also lung-protective ventilation does not = set it and forget it. Settings needed to maintain LPV will obviously change during a patient's course, something that experienced clinicians know.
Read 13 tweets
Yesterday's NEJM lead article provides little new info on the effectiveness of #remdesivir for #COVID19. It's based on a small, highly-selective sample and has no control group. I recommend waiting for RCT evidence. #medtwitter #medicaltwitter THREAD…
The study is predictably generating many headlines like this: 2/10…
And not enough headlines like this: 3/10…
Read 10 tweets
Long Thread warning. #EvidenceBasedMedicine
Chloroquine/hydroxychloroquine (Plaquenil)
Chloroquine phosphate (CP) and hydroxychloroquine sulfate (HCQ), antimalarial agents, have gained significant popularity for the management of COVID-19. Chloroquine
phosphate and hydroxychloroquine sulfate, which exert various anti-inflammatory and immunomodulatory effects and are widely used for the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), are substituted 4-amino quinoline compounds that differ only
by a hydroxy group. The attention is mostly due to in vitro data from several studies including a study from Wang and colleagues in February 2020, which demonstrated potent in vitro activity of chloroquine against SARS-CoV-2. This was, however, consistent with previous data for
Read 22 tweets
So @getadrip deleted their tweet about IV and IM medicines for £50, after I asked about regulatory issues.
Emails from "Richard" @getadrip are bizarre.
"We are not currently CQC registered as we do not fall within their scope and have not been informed otherwise by the CQC."
Again from @getadrip :

"All our products are MHRA approved and are prescribed by GMC Registered Doctors or Advanced Nurse Practitioners, all of whom have 10 - 25 years experience in the NHS individually.
"There are many Vitamin Drip providers within the UK, some of which have been operating for up to 10 years, they are also not regulated by the CQC ..., please see an example below:…
This is the strangest @CareQualityComm report ever.
Read 28 tweets

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