Discover and read the best of Twitter Threads about #FOAMcovid
Most recents (6)
Proposed COVID-19 Pathophysiology [Part 3 of (now) 4]:
Coagulopathy Strikes Back.
What happens when #COVID19 clashes with the world of hematology?
Buckle up again for a long one.
...let’s dive in like this macrophage (exploring all directions):
Coagulopathy Strikes Back.
What happens when #COVID19 clashes with the world of hematology?
Buckle up again for a long one.
...let’s dive in like this macrophage (exploring all directions):
First, what do you think is the predominant mechanism by which thrombosis occurs in COVID-19?
Where does thrombosis typically first occur?
I was feeling overwhelmed by all the laypress articles about #moralinjury and #burnout in frontline health care workers during #Covid_19 so I decided to do a deep dive into the literature on the mental health of workers during pandemics.
Here's what I found. #thread
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Here's what I found. #thread
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Seriously, so many laypress articles.
What evidence do we have on this, and further, what evidence do we have on strategies that mitigate these mental health issues in health care workers?
I presented these data the @UChicagoMed @UCCancerCenter grand rounds last week.
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What evidence do we have on this, and further, what evidence do we have on strategies that mitigate these mental health issues in health care workers?
I presented these data the @UChicagoMed @UCCancerCenter grand rounds last week.
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@UChicagoMed @UCCancerCenter But first, some definitions to set the stage:
Burnout, initially described by Dr. Maslach as the prolonged physical and psychological exhaustion related to a person's work. Not specific to medicine, although the definition has been honed for medicine (see slide). #burnout
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Burnout, initially described by Dr. Maslach as the prolonged physical and psychological exhaustion related to a person's work. Not specific to medicine, although the definition has been honed for medicine (see slide). #burnout
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Proposed COVID-19 Pathophysiology [Part 2 of 3]:
Enter the magnificent macrophage.
What do #COVID-19 and hemophagocytic lymphohistiocytosis (#HLH) potentially have in common?
...let’s continue our journey onward into the cytokine storm.
Enter the magnificent macrophage.
What do #COVID-19 and hemophagocytic lymphohistiocytosis (#HLH) potentially have in common?
...let’s continue our journey onward into the cytokine storm.
First, let’s briefly summarize what we covered before:
What mechanism may be partly responsible for heterogeneity of COVID-19 disease phenotype as well as its severity?
What mechanism may be partly responsible for heterogeneity of COVID-19 disease phenotype as well as its severity?
Correct! Antibody-dependent enhancement (ADE) is the result of producing sub-neutralizing antibodies which paradoxically enhance the rate of viral replication and severity of viremia.
Proposed COVID-19 Pathophysiology [Part 1 of 3]
What do #COVID-19 and #Dengue fever potentially have in common?
The answers have significant potential clinical implications in COVID-19.
Buckle up. It's a long one.
Let’s take a hematological walk on the zoonotic side.
What do #COVID-19 and #Dengue fever potentially have in common?
The answers have significant potential clinical implications in COVID-19.
Buckle up. It's a long one.
Let’s take a hematological walk on the zoonotic side.
Dengue is a flavivirus that is called “breakbone fever”, a nod to bone-breaking pains that occur during the infection.
There are four serotypes of the dengue virus.
Infection with one serotype does not fully protect one from contracting a different serotype.
There are four serotypes of the dengue virus.
Infection with one serotype does not fully protect one from contracting a different serotype.
True or false: The second or later infection with dengue is often much more dangerous.
"Cytokine Storm". The idiot's buzzword of the week. It makes you sound smarter if you say it often enough. When I first heard of it in 1994 it sounded AMAZING! Then this RCT came out showing it increased mortality. Ouch nejm.org/doi/full/10.10…
Next came rhAPC (drotrecogin). Don't knock out the immune system: we need it to survive. APC has signalling properties to modulate inflammation. NEJM PROWESS was touted a success! nejm.org/doi/full/10.10…
Just as we were celebrating and retrospective analyses showed efficacy correlated with drotrecogin reducing Il-6 levels, bad news came in and the dream turned sour nejm.org/doi/full/10.10…
A hematology @tony_breu-style tweetorial:
Why does lymphopenia occur in #COVID19?
A normal WBC count and lymphopenia are seen in patients affected by COVID-19, but why it occurs has bothered me since the pandemic onset.
The potential answer is surprising and interesting.
Why does lymphopenia occur in #COVID19?
A normal WBC count and lymphopenia are seen in patients affected by COVID-19, but why it occurs has bothered me since the pandemic onset.
The potential answer is surprising and interesting.
First, what do you think the mechanism is?
Does the degree of lymphopenia correlate with survival?
