Discover and read the best of Twitter Threads about #GI21

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#GI21 time for another #Tweetorial🧵 on


in a very 🎯 “Target-rich” disease

~3️⃣0️⃣% actionable findings

Interestingly we found more #FGFR🧬 fusions on liquid🩸than tissue 🔬. #OncoAlert
🧵2️⃣ #GI21
#Cholangiocarcinoma is the poster child of actionable aberrations & truly a 🎯“Target-rich” disease.

We focused on %numbers for aberrations for which there’s either an ✅approved drug, guideline endorsement, #clinicaltrials or even off-label reports/cases.👇🏾
🧵3️⃣ #GI21
We often don’t think of #ctDNA based platforms to be as sensitive for detecting fusions; when present it is real & an actionable finding.

Interestingly we found #FGFR🧬fusions
💭 maybe because of selection bias. #ctDNA filling the void. #OncoAlert
Read 12 tweets
@TumorBoardTues #TumorBoardTuesday
Thursday Case 🎀

🧑‍🎓Great discussion on the Tx of LAPC

✳️Most preferred FFX for this pt

➡️But the only PROSPECTIVE 📋 is w/gem-nab

➡️There are ✅ retrospective 📋 for FFX…

➡️For both, resection rate is 10-15% Image
@TumorBoardTues #TumorBoardTuesday
Thursday Case 🎀

Other options for LAPC:

➡️Clinical trials should be our 1st option, if available
✳️KRAS G12D/V siRNA + chemo
✳️Gem-Nab +/- FG-3019

➡️Radiation (despite negative data from LAP-07)

✳️2 abstracts @ASCO #GI21
@TumorBoardTues @ASCO #TumorBoardTuesday
Thursday Case 🎀

We had a poll on what is essentially 2nd line chemo for LAPC
✳️Not surprisingly most recommended gem-nab

➡️There are 2 abstracts @ASCO #GI21 on using nal-iri after progression on FOLFIRINOX

Any thoughts on this?🤔 Image
Read 8 tweets

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