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Good Morning #GImedTwitter

🌅🌄🌇Whether you are waking up in San Francisco…..or not (Curse you COVID-19😡)

🧑‍🏫Get ready for 3 packed days of presentations at #GI22

And to get the🧠started, we are going to share our
Top 10 Targeted Therapy Abstracts🎯

#TumorBoardTuesday
#TumorBoardTuesday

1⃣/
Once again HER2🎯💊is everywhere #GI22

👉The DESTINY trials have been👍4⃣T-DXd

✅DESTINY-CRC01
➡️T Yoshino, et al "RAPID" Abs 119
⏩53 "Group A" HER2+ RASWT CRC pts
⏩ORR 45%, mOS 15.5 mos
👍Even with prior HER2 Tx
😨But GR>=3 AEs in 65% of pts, 9% ILD
#TumorBoardTuesday #GI22

2⃣/
✅DESTINY-Gastric 01
➡️K Yamaguchi, et al "RAPID" Abs 242
⏩Randomized Ph II trial of >=2nd line💊
👉T-DXd vs. Physician’s choice (PC) which was Iri or Paclitaxel
⏩mOS 12.5 v 8.9 mos
⏩ORR 51% vs 14%
😨But Grade >= 3 AEs were 86% vs 57%
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