Discover and read the best of Twitter Threads about #GRABSensors
Most recents (2)
1/6 PGE2 is one of the principal bioactive prostaglandins, critical signaling lipids implicated in body homeostais and pathegenic inflammatory response, yet its in vivo dynamics are largely unknown. #GRABsensors #Prostaglandins
2/6 Now we newly developed a fantastic GRAB-PGE2 sensor for monitoring PGE2 dynamics with high spatiotemporal resolution in vivo!
3/6 Using the newly developed GRAB-PGE2 sensor, we detected spatiotemporal PGE2 release during inflammation and seizures in the mouse dorsal cortex by mesoscopic imaging.
1/4 A toolkit of new GRAB fluorescent neuropeptide sensors from Li Lab! These sensors can detect neuropeptides at nanomolar concentration with a robust increase in fluorescence. #GRABSensors #Neuropeptide 
2/4 GRAB-CRF1.0 reveals in vivo CRF dynamics in the cortex and hypothalamus induced by stressful experiences using fiber photometry and 2-photon imaging in mice.
3/4 We used these GRAB neuropeptide sensors to measure the spatiotemporal dynamics of endogenous SST release in isolated pancreatic islets and to detect the release of both CCK and CRF in acute brain slices.
