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Delighted to share with you a new exciting #publication in @eLife from my previous lab at @CIB_CSIC that finally came out today.
This paper challenges the previously accepted model of how #microtubules / #tubulin #estructure changes upon #GTP #hydrolysis.
elifesciences.org/articles/50155
This paper challenges the previously accepted model of how #microtubules / #tubulin #estructure changes upon #GTP #hydrolysis.
elifesciences.org/articles/50155
Microtubule #lattice #expansion has been previously thought to be consequence of GTP hydrolysis.
In this work, thank to the use of several #biochemical, #biophysical, and #bioinformatics techniques, showed that the #tubulindimmer expansion does not occur upon hydrolysis.
In this work, thank to the use of several #biochemical, #biophysical, and #bioinformatics techniques, showed that the #tubulindimmer expansion does not occur upon hydrolysis.
Microtubules shear-flow alignment and X-ray #fibrediffraction experiments together with #CryoEM data, and different use of analogues showed that #GDP-#BeF3 dimmers resembles the GTP bound state of tubulin, since BeF3 mimics the gamma-phosphate function of GTP, stabilising the MTs
