Discover and read the best of Twitter Threads about #Gastriccancer

Most recents (8)

Science behind the Study:

#GastricCancer is a common and often lethal cancer that, like cervical and liver cancer, can be attributed in large part to an infectious cause.

Full editorial on gastric cancer risk available here: nej.md/3JQQY4v 1/15
In the case of gastric cancer, the infectious agent is a bacterium, Helicobacter pylori. Until now, hereditary forms of gastric cancer were thought to be limited to a small percentage of CDH1-mutant cases. 2/15 Helicobacter pylori A spiral-shaped, flagellated, gram neg
In this week’s issue of NEJM, Usui et al. provide compelling evidence for a substantial contribution from inherited (germline) variants in nine cancer genes to the risk of gastric cancer. Read the study here: nej.md/40Br5MC 3/15
Read 15 tweets
@TumorBoardTues 1/15 #TumorBoardTuesday #GastricCancer #OncTwitter
Here goes

🎬Starting out with an overall poll Q

When a new advanced GC/GEJ patient presents to your clinic, your institution reflexively tests for which of the following?
@TumorBoardTues 2/15 #TumorBoardTuesday

68y/o with poorly diff gastric cardia adeno, diffuse LAD, +peritoneal mets.

🧬Biomarkers HER2-, PD-L1-, MSS
🧪Pre-screened for trials & FGFR2b-, Claudin18.2+
🔦Enrolls in frontline SPOTLIGHT trial.

❓What is Claudin18.2?
❓What is SPOTLIGHT?
@TumorBoardTues 3/15 #TumorBoardTuesday

✨Claudin18.2 (CLDN18.2)✨

Transmembrane protein typically present in tight junctions of gastric mucosal cells, maintains barrier function of gastric mucosa, & prevents leakage of H+ in gastric acid through paracellular pathways.
Read 21 tweets
😳🤯The hour flew by & none of us noticed!!

🙏🏽 @FogacciJoao for bringing the 🇧🇷 flair to #TumorBoardTuesday & #GastricCancer!!

🏆Remember your🆓CME

Look for Case Wrap Up🎀 04/28/22

📅Mark your calendar for 05/10/22 8pm ET when @FlavioRochaMD joins our #VirtualTumorBoard!!
Remember #TumorBoardTuesday education goes beyond Twitter - we offer 🆓 CME!!

Pick up your🏆#CME & NOW #MOC(‼️) by answering quick questions regarding a case similar to @FogacciJoao’s‼️

🔗ALL CME: integrityce.com/tbt

🔗 post rationale: bit.ly/3kcIXdv

🇧🇷🎁🇧🇷
#PostTest Q1️⃣ #CME #TumorBoardTuesday @MPishvaian

🤔Now that @FogacciJoao schooled us through updates on immunotherapy for #GastricCancer, how would you answer these 2 quick ❓

🧬 Which are potentially useful immunotherapy biomarkers in gastric cancer?
Read 21 tweets
🚨 #CME Thursday 🚨

This week at #TumorBoardTuesday @W_Park_MD discussed FGFR inhibitors in #BiliaryTractCancer #CCA...and how to find FGFR fusions!

Check out the questions below, and tap the link to claim your free #CME...and stay tuned for a special edition of case wrap up! Image
#PostTest Q 1️⃣ #CME #TumorBoardTuesday
👉🏽 ALL CME🔗 integrityce.com/tbt

🤔 What is a molecular biomarker for an FDA approved🎯💊in #Cholangiocarcinoma

#OncTwitter #GeneTesting #CCA
#PostTest Q 2️⃣ #CME #TumorBoardTuesday
👉🏽 ALL CME🔗 integrityce.com/tbt

🤔 To detect 🧬 gene rearrangement what is the preferred method❓

#OncTwitter #GeneTesting #CCA
Read 14 tweets
Good Morning #GImedTwitter

🌅🌄🌇Whether you are waking up in San Francisco…..or not (Curse you COVID-19😡)

🧑‍🏫Get ready for 3 packed days of presentations at #GI22

And to get the🧠started, we are going to share our
Top 10 Targeted Therapy Abstracts🎯

#TumorBoardTuesday
#TumorBoardTuesday

1⃣/
Once again HER2🎯💊is everywhere #GI22

👉The DESTINY trials have been👍4⃣T-DXd

✅DESTINY-CRC01
➡️T Yoshino, et al "RAPID" Abs 119
⏩53 "Group A" HER2+ RASWT CRC pts
⏩ORR 45%, mOS 15.5 mos
👍Even with prior HER2 Tx
😨But GR>=3 AEs in 65% of pts, 9% ILD
#TumorBoardTuesday #GI22

2⃣/
✅DESTINY-Gastric 01
➡️K Yamaguchi, et al "RAPID" Abs 242
⏩Randomized Ph II trial of >=2nd line💊
👉T-DXd vs. Physician’s choice (PC) which was Iri or Paclitaxel
⏩mOS 12.5 v 8.9 mos
⏩ORR 51% vs 14%
😨But Grade >= 3 AEs were 86% vs 57%
Read 11 tweets
1/10 #TumorBoardTuesday
Thursday Case🎀
This week’s case: pt w #GEA not responding to FLOT w dMMR/MSI. Receives 3 doses of pembrolizumab->pCR!

💡Biomarker-based IO can be v successful, but better biomarkers needed‼️
➡️Explore wrap up below re: deploying IO in #UGI Image
2/10 #TumorBoardTuesday

👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick ❓
Here is the post-test 🔗: bit.ly/3EgtZeE

ALL CME 🔗: integrityce.com/tbt Image
3/10 #TumorBoardTuesday
Thursday Case🎀

Take🏠messages:
We discussed #GastricCancer & immunotherapy (IO)
✅dMMR/MSI quite common- 8-22% of non-metastatic cases
✅Chemo less effective in dMMR disease, particularly 5-FU
✅High pCR with upfront IO
✅ctDNA may be a key biomarker
Read 13 tweets
1/9 #TumorBoardTuesday
🔬A discussion on EBV+ #GastricCancer-important differences in tx led by @SunnieSKim

➡️Here's the Thursday Case🎀

👉👉Don’t forget to pick up🆓 #CME by answering 2 quick❓

Here's post-test🔗: bit.ly/3yRO1cb

ALL CME🔗: integrityce.com/tbt
2/9 #TumorBoardTuesday Thursday Case🎀
Take🏠:

#GastricCancer are NOT all the same; ≈10% EBV+

✅EBV+ likely⬆️PD-L1; exclusive w HER2 mut
✅EBV+ responsive to immunotx
✅Should EBV🧪be standard?

📚We captured as much of @SunnieSKim’s chat as we could:

twitter.com/i/events/14332…
3/9 #TumorBoardTuesday Thurs Case🎀
@SunnieSKim tweetorial

✅8-10% of GC =EBV+
✅Methyl of viral/host DNA➡️GC
✅⬆️in👨‍🦰/young pts
✅Diffuse type, lymphoid infiltrate & prox loc
✅🔦: hypoechoic submuc nodule
✅⬆️CD8+ TILs & immune 🧬 (IFN-g)
✅TP53, HER2 changes✖️common in EBV+
Read 11 tweets
#TumorBoardTuesday

That was a super🦸high energy⚡️ @TumorBoardTues case discussion led by @AJacomeMD

🙏for joining

➡️Here is this week's Thursday Case🎀

👉👉Don't forget to pick up your🆓#CME credit by answering these 2 quick❓s

Here's the post-test🔗
integrityce.com/posttest3-23
#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

We had an great discussion about gastric cancer, and FGFR-fusions

We captured as much as we could in this moment:
twitter.com/i/events/13739…
#TumorBoardTuesday
Thursday Case🎀
(Case from 03/23/21)

@AJacomeMD presented a case of a young patient with metastatic gastroesophageal cancer

🔬Poorly-diff adenoca, signet-ring cells, pMMR, HER2-, CPS 0

Most of us would have recommended FOLFOX Image
Read 11 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!