Discover and read the best of Twitter Threads about #Genomic

Most recents (10)

BCG analyzed 🔬 🇺🇸, 🇫🇷 , 🇩🇪 , 🇮🇹, 🇪🇸 Outlook

Testing's likely to follow similar trajectories

Peak COVID demand occurring in the seasonally affected first quarters of 2021 & 2022

#Novacyt #ALNOV #NCYT

bcg.com/en-in/publicat…
BCG anticipate continued need for testing in 2023 & 2024

Even if vaccines prove to be highly effective, the need to test people for COVID-19 will continue, for at least five reasons

#Novacyt #ALNOV #NCYT
TESTING DEMAND DRIVERS:

. Epidemiology of the COVID-19 🧬
. Impact of the vaccines 💉
. Impact of therapeutics 💊
. Government policy 📜

What makes a good test 🔍
#Novacyt #ALNOV #NCYT
Read 5 tweets
It changes everything about what we understand, this virus is bit too much for mankind. Challenges aplenty but #Science will take us through !
Read 9 tweets
Our nation-wide study on the #genomic #epidemiology of #SARS-CoV-2 #superspreader_events in #Austria is out in @ScienceTM !

doi.org/10.1126/scitra…

Please find the highlights in this thread. 1/8
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic. Explore our data and data-driven narratives at #NextstrainAustria sarscov2-austria.org ! 2/8
#Epidemiological and #Phylogenetic data revealed the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C. 3/8
Read 8 tweets
🎉CELEBRATION ALERT!! We reached 10K followers @NatureCancer - massive thank you to our wonderful community for the warm welcome! Given it is also 10 months of our online life, here are some of our best articles (although all are *fantastic*) #thread 1/n

#10atNatureCancer
January @NatureCancer: Nabel &co @SanofiUS develp #trispecific antibodies against CD3, CD28 and CD38, with preclinical efficacy and safety in humanized mice and NHPs 2/n

go.nature.com/30GlQyH
rdcu.be/b78Zr

#10atNatureCancer
February @NatureCancer: Golub and Co @broadinstitute develop PRISM, a tool for non-oncology drug repurposing in #cancer 3/n

go.nature.com/36zCxQh
rdcu.be/b78ZE

#10atNatureCancer
Read 12 tweets
Rapid whole genome (🧬) sequencing (rWGS) is one of the most exciting (and benevolent) collisions of #AI and #genomics I can think of.

rWGS can diagnose a critically ill child in minutes where previously it took years.

illumina.com/company/news-c…
A few years ago, Illumina ($ILMN) and Rady Children's Hospital (@RadyGenomics) collaborated to offer sequencing services for diagnosing critically-ill infants and toddlers.

Roughly 70% of rare diseases are genetic and they can take five years to diagnose.
As sequencing costs dropped and #AI got faster, this collaboration became Project Baby Bear: a pilot study for rWGS's diagnostic yield, clinical utility, and health economics in practice.

Several innovative companies joined Rady's in creating a rapid diagnostic pipeline.
Read 14 tweets
#RareDiseases are not rare. One example is Hyper-IgD Syndrome, an #autoinflammatory / #PrimaryImmunodeficiency disease. Wonderful collaboration extending over 5 years between Kozhikode Medical College, CMC Vellore and CSIR-IGIB as part of the #GUaRDIAN journals.plos.org/plosone/articl… Image
Our #genomic analysis suggests that a few variants account for the majority of the patients with HIDS in South #India with implications in #diagnosis, as well as in the development of cost-effective approaches for #genetic #diagnosis and #screening

@Primary_Immune @MoHFW_INDIA
Read 3 tweets
📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n) Image
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n) Image
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n) Image
Read 32 tweets
Check out the latest preprint from the lab on "Integration of #Genomic & Multi-tissue #proteomic data in neurodegenerative diseases" lead by @chengran2020 @WUSTLdbbs in @ccrugom lab at @WUSTLmed supported by @cziscience via @medrxivpreprint medrxiv.org/content/10.110… #tweetorial ⬇️
This is the first #proteomic study that uses high throughput pQTL in neurological relevant tissues to identify novel genetic loci regulating protein levels, which will improve our understanding of the biology of #Alzheimers, #Parkinsons, & other neurodegenerative diseases
We identified hundreds of novel pQTLs in CSF, plasma, & Brain linking novel genes, biomarkers and drug targets with #Alzheimers, #Parkinsons
Read 10 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets
Just published: A new 5-paper Series, with contributions from @genome_gov, focuses on the exciting and maturing area of #genomicmedicine, encompassing the use of individuals’ genetic information to guide clinical treatment hubs.ly/H0k35bk0 Image
@genome_gov @NIH @GenomicsEngland "As this Series emphasises, #genomics is now an essential part of high-quality patient care in rare disease, cancer & those areas of mainstream medicine where pharmacogenomics & the need for precision diagnostics is growing." Comment by M Caulfield et al hubs.ly/H0k6Q-M0 Image
@genome_gov @NIH @GenomicsEngland @QMUL @QMULWHRI @GreatOrmondSt "I see genomics as providing another way of assessing risk and enabling better management of our patients"

Profile: Teri Manolio, Director of Genomic Medicine at @genome_gov & lead author of our new Series on #genomicmedicine hubs.ly/H0k7Pd00
Read 7 tweets

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