Discover and read the best of Twitter Threads about #GeorgeYoung
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It’s not all Spike! 👉Emergence of novel subgenomic mRNAs in SARS-CoV-2. Sharing our latest preprint with work led by @Artisplicer, showing effectively the coronavirus analogue of entirely new promoters and splice sites emerging in the genome 🆒 biorxiv.org/cgi/content/sh…🧵 1/n 
This process is a hallmark of coronavirus evolution and adaptation to new hosts, and we are seeing it in real-time… It’s also reminiscent of eukaryotic gene evolution via exon shuffling and duplication of promoter and regulatory elements. 2/n
The story starts w/the B.1.1 lineage (ancestor to Alpha, Gamma & Omicron), which is defined by a double mutation in nucleocapsid: R203K & G204R. Looks unremarkable, but it makes a new TRS-B site (that’s the “splice” site), upstream of a start codon in good Kozak context. 3/n
