2/5 "The #gut #microbiome is a key modulator of body temperature variation both in #health and critical illness, and is thus a major, understudied target for modulating #physiologic #heterogeneity in #sepsis."

3/5 The Carrington Event was the most intense geomagnetic storm in recorded history, peaking from September 1 to September 2, 1859 during solar cycle 10.

Read 5 tweets

Todd Maderis, ND

@dr_todd

The Effect of #Glyphosate on the #Gutmicrobiome and Neurocognitive Function
sciencedirect.com/science/articl…

1/5 Glyphosate is the active ingredient in the herbicide #RoundUp. In 1996 #geneticallymodified soybeans that could tolerate Round Up were introduced. At that time, Round Up made up just 3.8% of herbicides in use. By 2007 glyphosate use was more than double the next herbicide.

2/5 Glyphosate blocks an enzyme used by plants, bacteria, fungi, and algae, including beneficial bacteria in our #gut. Pathogenic bacteria Clostridia and Salmonella are not affected by glyphosate, allowing them to survive.

Read 6 tweets

Christian Thoma MSc PhD

@DrChristianThom

@gerdosi

It's not just what you eat that influences your #gut #microbiome, but also the medication (not just antibiotics).

We now need to be thinking about that more carefully when studying #diet, #prebiotics, #probiotics, #gutbrainaxis and the #microbiota

#Gastroenterology

@gerdosi

https://twitter.com/JonathanStineMD/status/1582730016395526145

"Individuals exposed to multiple drugs, polypharmacy, showed distinct gut microbiome structures harboring significantly more abundant upper gastrointestinal species and several nosocomial pathobionts due to additive drug effects."

"Polypharmacy was also associated with microbial functions, including the reduction of short-chain fatty acid metabolism and increased bacterial stress responses."

Read 4 tweets

gladfellow

@gladfellow

https://twitter.com/drmoghes/status/1572598043236782082

#Peacetime #Reflections
To get a permanent liberation from #migraine, we, as the sufferers, need to be deeply respectful and committed to ourselves at both dimensions - body and mind. 1/7

https://twitter.com/drmoghes/status/1572598043236782082

What goes into the #gut and #mind determine how intense and lasting would the #pain and #affliction be! A doctor can help only to some extent. #Painkillers are affronts to the body and mind. They stop working anyway after a while. 2/7

As sufferers, we need to own it up. In an utterly devastated and vexed state, we need to turn around with fire in heart and tell ourselves - 'Enough of playing games with myself! Let me take charge of my own inner sacred space, deterge it, make a temple of it - NOW or NEVER' 3/7

Read 8 tweets

KotzDichAus

@KotzDichAus

Ich hab hier quasi keine Reichweite und das ist für mein heutiges Vorhaben auch gut so.
Ich muss es mir von der Seele schreiben.
Mein persönliches #Ahrtalflut Protokoll.
Uhrzeiten ab „nach Mitternacht“ sind nur ungefähr Angaben.
1/x
#jahrestag #einerkatastrophe #Ahrtal #sinzig

2/x
17:00 Uhr startet mein Onlineunterricht. Als Dozentin aus dem heimischen Wohnzimmer.
Bis auf einen weiteren verregneten Tag und ersten „Ahr Hochwasser“ Meldungen (die hier alle paar Sommer mal wieder kommen), war es bis dahin ein normaler Tag für mich. #Flutkatastrophe

3/x
Kinder (19 & 17) sowie Mann waren auch daheim.
18:30 Uhr im Flur bemerke ich meinen Sohn hektisch werden. Er, Mitglied der SEG Behandlung des DRK. Örtl. DRK WA-Gruppe explodiert.
SEG Alarm - sofort bereit machen.
Ich sage zum Sohn, er soll auf sich aufpassen. #jahrestag

Read 67 tweets

Leigh A. Frame 🍎🥕🍋🥦🍇

@PhD_Leigh

Now we'll talk #polyphenols and #PrecisionNutrition in this next science packed session at #Nutrition2022. #NutritionLiveOnline

Oh look the #microbiome is here too! 🥰👏🥳 Yes, polyphenols are key to the #GutMicrobiome. Let's learn more.
#Nutrition2022 #NutritionLiveOnline

But first the #metabolome and polyphenols. #Nutrition2022 #NutritionLiveOnline

Read 12 tweets

Leigh A. Frame 🍎🥕🍋🥦🍇

@PhD_Leigh

Good morning! Starting day 2 with another of my favorite #nutrition topics: the food matrix. What does that mean for #health? Food is not simply the sum of its parts. 🤓
#Nutrition2022 #NutritionLiveOnline

@HolscherLab

First up, one of my colleagues in nutrition and the #gut #microbiome, @HolscherLab. Let's #science!
#Nutrition2022 #NutritionLiveOnline

The matrix of foods affects the bioaccessibility of nutrients.
#Nutrition2022 #NutritionLiveOnline

Read 10 tweets

RiseAndResist

@FrontLineExHero

#1 #Covid19 #Supplement thread for #LongCovid #LongHaul #PostCovid. This may help, if you suffer from #fatigue #brainfog #jointpain #inflammation #weakness #depression #anxiety #SOB #clots #fibrosis #myocarditis #heartattack #stroke #alz #memory frontiersin.org/articles/10.33…

#2 B-COMPLEX/MULTI VITAMIN. Buy a liposomal or other form that increases bio-availability. Take 1 capsule w/Breakfast and Lunch. If you have stomach upset, try sublingual (under tongue) EZ Melt B-Complex in AM & Multi w/iron for Dinner. amazon.com/Liposomal-Meth…

#3 OMEGA 3s. Fish Oil, Krill Oil, Algae Oil are all good sources of Omega 3. Be careful the EPA/DHA ratio. EPA helps with inflammation/DHA helps with cognition. You need both! Opt for a 1:1 or 2:1 ratio of DHA to EPA (2:1 ratio eg. 800 DHA/400EPA) amazon.com/3Care-Concentr…

Read 93 tweets

Omar Mossad

@OmarMglia

@NatureNeuro

Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159…

1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature"

2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level?

Read 13 tweets

Nicole Kippels NRW 🛑🛑🛑#TeamKinderschutz

@KippelsNicole

@OlafScholz

1/6
Wir wollen es Mal in #Euro hören und sehen, was #KINDER in #Deutschland wert sind!
@OlafScholz
@HendrikWuest
@Karl_Lauterbach
Also:
Sie sind keine #Luftfilter wert 100€
Sie sind keine #Maske wert 20€ p.M
Sie sind keine #gut ausgestatte #Schulen wert. 1000€ p.J.

2/6
Sie sind keine #PCRtests Wert.70€
Sie sind es nicht #Wert durch die #Unfallkasse vor den #Folgen einer #Coronainfektion geschützt zu sein, da ihnen das #Recht auf #Beweismittel #PCRtest genommen wird.
Sie sind es nicht #Wert, dass es für #Kinder Studien zu #LongCovid gibt.

3/6
Das heißt, #Familien sind die #verlierer der #Pandemie!
#Kinder und #Familien werden von #Politikern skrupellos durchseuchen, ohne auch nur über die #Folgen einer #Coronainfektion umfassend informiert worden zu sein.
Die #Familien werden dieses #Leid der Kinder tragen müssen

Read 6 tweets

John Damianos, M.D.

@john_damianosMD

@aeprobio

While we're beginning to understand more and more about the #microbiome, research on the #mycobiome (fungi 🍄) is in its infancy. Here is my summary of 🔑 points from @aeprobio's seminar on the latest research on fungi and the gut!

#GITwitter

Bacteria in the #gut outnumber fungi as a class, but at the individual species level can occur in the same numbers.

Most #gut fungi belong to Ascomycota or Basidiomycota

Read 43 tweets

John Damianos, M.D.

@john_damianosMD

@DrPraegers

Thank you so much to @DrPraegers for having me to discuss the effects of plant-based diets on the #gut #microbiome! Here are my slides for all to see! 😃

🍅🥑🧅🍑🥦🍒🫑🍊🌶️🍎🍆🍊🫒🍓🥒🍉🥗🥝🦠

#medicine #medtwitter #diet #nutrition #GITwitter #GI #guthealth #health

Just as we do things for heart health and brain health, our #microbiome is an organ of its own (the size of a 🥭), so we need to take care of it!

Read 30 tweets

John Damianos, M.D.

@john_damianosMD

Buckle up! This 🧵 is a deep dive into the #physiology of defecation, the mechanics of pooping! 🧰 🚽 💩

nature.com/articles/s4157…

#medicine #MedEd #science #GITwitter #GI #gut #motility #constipation #IBS

Defecation requires
1. intact #GI tract
2. coordination of many systems: neural (enteric nervous system, modulated by the peripheral somatic, autonomic and the CNS); muscular (smooth and striated); hormonal (endocrine and paracrine); and cognitive (behavioural and psychosocial)

#Constipation is the3⃣rd most common #GI symptom

💰 Annual cost of fecal incontinence and constipation: $1,594 - $7,522

Read 31 tweets

John Damianos, M.D.

@john_damianosMD

@BritSocGastro

Here are the new @BritSocGastro guidelines for #IBS in @Gut_BMJ! I'll summarize in 🧵 ⬇️⬇️⬇️!

😖💩🦠🧠🥦🍞💊

#GITwitter #GI #gut #braingut #motility #DGBI #FGID #microbiome #probiotics #MedTwitter #MedEd

gut.bmj.com/content/early/…

🧑‍⚕️-😷
Doctor-patient communication
🧑‍⚕️A strong 🧑‍⚕️-😷 relationship is fundamental to the management of #IBS
😷Patients want their 🧑‍⚕️ to ⬆️empathy, support and information about the nature of IBS, diagnosis, and treatment options

@RomeFoundation

DIAGNOSIS
🩸New pt: CBC, CRP or ESR, celiac serology and, if <45 w diarrhea, fecal calprotectin
➕Make POSITIVE diagnosis based on @RomeFoundation criteria
➡️Refer to #GI when: diagnostic doubt, pt w symptoms that are severe or refractory to 1stline tx,or when pt wants specialist

Read 16 tweets

John Damianos, M.D.

@john_damianosMD

Foods in our #diet can alter the pro-inflammatory vs anti-inflammatory milieu of the intestinal #microbiome.

See 🧵 below for the findings!

🥬🍑🍅🍠🥚🍎🧀🍆🫒🫓🍇🥦🥑🥥🥯🌶️🧄🥖

#GITwitter #GI #gut #nutrition

gut.bmj.com/content/early/…

🥖 🥜 🐠 🌰
Breads, legumes, fish and nuts⬇️several pro-inflammatory pathways:
🫓⬇️pathogenic growth factors & endotoxins
🫓⬇️ pathogenic E. coli, Bacteroides fragilis, parabacerioides
🫓⬆️ammonia detoxification pathway

🌰🐟 🍑🥦
Nuts, oily fish, fruit, vegetables & cereals ⬆️short-chain fatty acid producers
🫑⬆️Faecalibacterium prausnitzii, roseburia hominis, and more

Bacteria ferment fiber and pectins to acetate and butyrate.

SCFAs have anti-inflammatory effects on the mucosa!

Read 20 tweets

John Damianos, M.D.

@john_damianosMD

@AmCollegeGastro

A little late but better late than never! ⌚️ Here's a recap of @AmCollegeGastro Virtual Grand Rounds by @ScottGabbardMD on...... FUNCTIONAL DYSPEPSIA!
🤢🤢🤢

This is a VERY common entity that is underdiagnosed! #MedTwitter take notice!

#GITwitter #GI #gut

DYSPEPSIA = epigastric #pain. (can be associated with any other upper #GI symptom such as epigastric fullness, nausea, vomiting, or heartburn).

Dyspepsia is COMMON, and most cases are FUNCTIONAL (i.e., caused by brain-gut axis dysfunction)!

Like all disorders of gut-brain interactions FD pathophysiology is❌completely understood, but is thought to be complex+multifactorial. Components include
🤢disrupted duodenal barrier
🤢altered duodenal #microbiome
🤢dysmotility
🤢visceral hypersensitivity
🤢psychosocial stress

Read 22 tweets

John Damianos, M.D.

@john_damianosMD

@AGA_CGH

Let's talk about something common, hard to treat, and often misunderstood: CHRONIC BLOATING AND DISTENSION!

A 🧵 summarizing from the excellent @AGA_CGH article cghjournal.org/article/S1542-…

#GI #GITwitter #motility #IBS #DGBI #FGID #microbiome #health #MedEd

🟢Bloating: subjective sensation of gassiness, trapped💨, or a feeling of pressure or being distended w/o obvious visible distension.

🟢Distension: objective physical manifestation of an⬆️in abdominal girth. Patients commonly say they look like 🎈 or 🤰

Bloating and distension are COMMON

🔴16-31% in the general population

🔴Women > men

🔴66-99% in #IBS

🔴IBS-C > IBS-D

🟢Bloating and distension are distressing to patients and ⬇️quality of life

Read 13 tweets

Matt Snelson

@Matt_Snelson

@sihmin_tan

Latest paper is up! We fed mice high protein diets for 24 weeks and measured the #microbiome 🦠, #kidney function and #gut leakiness. Here's what we found: onlinelibrary.wiley.com/doi/abs/10.100… @sihmin_tan @MelindaCoughlan @MonashDiabetes

1) high protein diets alter the microbiome...but what's interesting is when we looked at the predicted metagenomes (using picrust2) we saw⬇️BCAA synthesis and⬆️urea cycle pathway.

2) the high protein diet caused inflammation and intestinal permeability:
⬆️ plasma endotoxin
⬆️ plasma MCP1
⬆️ TNFα expression in jejunum and ileum
⬇️ occludin expression in jejunum

Read 5 tweets

John Damianos, M.D.

@john_damianosMD

@AmCollegeGastro

🚨New @AmCollegeGastro guidelines for the treatment of irritable bowel syndrome! I will summarize in this🧵 ⬇️⬇️⬇️

journals.lww.com/ajg/Abstract/9…

Authors: #BrianLacy, @MarkPimentelMD, @dbrennerGIMD, @umfoodoc, @drlauriekeefer, @MLongMD, @BMoshiree

#GITwitter #GI #IBS #gut #MedEd

🔘In pts w diarrhea, rule out #celiac disease🍞
🔘In pts w diarrhea + no🚨features, check fecal calprotectin/fecal leukocytes AND CRP to rule out #IBD
🔘❌routine 💩testing for enteric pathogens in #IBS
🔘❌colonoscopy in IBS if <45 and no🚨s
🔘Make POSITIVE IBS dx (Rome), ❌DOE

🔘Identify #IBS subtype to target therapy
🔘❌testing for food allergies/sensitivities
🔘Test anorectal physiology in pts w IBS + symptoms suggestive of pelvic floor disorder +/or refractory #constipatoin
🔘Limited trial of low-#FODMAP #diet
🔘✅soluble fiber,❌insoluble fiber

Read 7 tweets

John Damianos, M.D.

@john_damianosMD

@AmCollegeGastro

Recapping @AmCollegeGastro's #VirtualGrandRounds on #IBS! Let's begin!
🟣IBS can be diagnosed with the Rome criteria
🟣Making a positive diagnosis is very helpful to patients, many of whom have gone years without a name for their symptoms

@AmCollegeGastro

#IBS is heterogeneous, and so are its pathogenesis and pathophysiology.
🟣Identifying underlying factors in patients can help target treatment!

@AmCollegeGastro

@AmCollegeGastro

Important principles when diagnosing and treating #IBS.

@AmCollegeGastro

Read 34 tweets

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