Discover and read the best of Twitter Threads about #HSV2
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A few years ago, @HShin_Lab developed a new vaccine strategy called 'Prime & Pull' - T cells are pulled into target tissue with chemokines, as #HSV2 vaccine strategy. Now, @SmitaGopinath shows that topical aminoglycosides = potent 'Pull' agent 👇🏽(1/n)
jimmunol.org/content/early/…
jimmunol.org/content/early/…
This finding follows @SmitaGopinath's earlier work that aminoglycoside antibiotics applied to the genital mucosa induces potent interferon-stimulated genes including CXCL10. Effector CD8 T cell expressing CXCR3 are recruited to the tissue. (2/n)
nature.com/articles/s4156…
nature.com/articles/s4156…
Single application aminoglycoside antibiotics are advantageous over recombinant chemokines because they are 1) approved for human use, 2) cheap, 3) effective. #HSV2 #vaccine
Prime & Pull also is very effective when used therapeutically @peowenlu. (3/n)
nature.com/articles/s4154…
Prime & Pull also is very effective when used therapeutically @peowenlu. (3/n)
nature.com/articles/s4154…
