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This week's #Twitterjournalclub was prepared by @alexlin0528
It's the #HelpICUtrial (the hospital-based evaluation of laxative prophylaxis in ICU) which was published in the Journal of Critical Care 52 (2019) 86-91…
570 adult mechanically ventilated and enterally fed patients were enrolled
Single ICU: cluster-crossover trial. Three pods in a single ICU each randomized to one of 3 regimens for 4 months with rolling crossover.
Participants were randomly allocated to:
A-One coloxyl with senna BD from day one, OR
B-Two coloxyl with senna + 20ml lactulose BD from day 3, OR
C-Two coloxyl with senna + 20ml lactulose BD from day 6
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