Discover and read the best of Twitter Threads about #Heritability
Most recents (5)
Discovering the genetic roots of diseases just got easier!
Our study sheds new light on the heritability and pleiotropy shared across diseases using a novel method that can scale to millions of individuals.
#heritability @UCPH_CPR
medrxiv.org/content/10.110…
Our study sheds new light on the heritability and pleiotropy shared across diseases using a novel method that can scale to millions of individuals.
#heritability @UCPH_CPR
medrxiv.org/content/10.110…
The study highlights the importance of heritability in disease development and trajectories.
Our study further confirms previous findings and even discovers new sex-biased diseases with heritable components and different disease etiologies.
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Our study further confirms previous findings and even discovers new sex-biased diseases with heritable components and different disease etiologies.
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With results important to the design and interpretation of genetic, genome-wide association and epidemiological studies.
The results of our comprehensive study will be available for the entire community!
Keep an eye out for our upcoming website with all the findings.
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The results of our comprehensive study will be available for the entire community!
Keep an eye out for our upcoming website with all the findings.
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As promised, here is my #tweetorial for our @capra_lab @NatureComms paper! Interested in complex trait #genetics, #heritability, #Evolution , or #Neanderthals ? 🧬
Paper: nature.com/articles/s4146…
"Behind the paper" article: natureecoevocommunity.nature.com/posts/uncoveri…
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Paper: nature.com/articles/s4146…
"Behind the paper" article: natureecoevocommunity.nature.com/posts/uncoveri…
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We have examples of how Neanderthals gave Eurasians individual genetic variants that contribute to traits; however, most medically/evolutionarily relevant traits are complex, with contributions from thousands of parts of the genome. We wanted something more comprehensive...
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We use partitioned heritability to investigate the relationship between introgression and diverse traits. First, we show that genomic regions with Neanderthal ancestry are depleted of heritability for all traits considered, except those related to skin and hair.
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Excited to present my first @capra_lab PhD project in today's @GeneticsSociety's @AJHGNews!!
Interested in #3Dgenome structure, complex trait #heritability, and/or evolutionary constraint?
cell.com/ajhg/fulltext/…
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Interested in #3Dgenome structure, complex trait #heritability, and/or evolutionary constraint?
cell.com/ajhg/fulltext/…
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By synthesizing topologically associating domain (TAD) maps across 37 diverse cell types with 41 genome-wide association studies (GWASs), we investigate the differences in disease association and evolutionary pressure on variation across the 3D genome landscape.
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We know that TAD boundary disruption by SV can lead to developmental disease and cancers. (Thus, selection acts against these SVs).
But what about the relationship between common human variation in TAD boundaries (eg. SNPs) and associations with complex traits?
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But what about the relationship between common human variation in TAD boundaries (eg. SNPs) and associations with complex traits?
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I just read Irreversible Damage by @AbigailShrier about the phenomenon of soaring rates of F to M transition in girls and young women. Bravo to her for highlighting this, it should be a subject of societal concern — why is it happening, what are the risks? (Thread)
I found it puzzling however that the book offered a purely sociological theory — that girls are choosing to transition due to social contagion, subtle pressures from professionals, and a desire to alleviate pains of anxiety, depression, isolation. To me, this is dubious.
Sadly, #IrreversibleDamage was strangely devoid of *any* discussion of biological development of gender identity. There are 4 decades of scientific literature showing how gender (the brain's sex) is shaped in early development, sometimes shaped by abnormal hormonal exposures.
aei.org/articles/the-2…
Extravagant success of Ashkenazi #Jews in wide range of intellectual domains serves as solid refutation to already exhausted #woke narrative of oppression, victimhood, & intersectionality. Why?/1
#IQ #psychology #intelligenceresearch #groupdifferences
Extravagant success of Ashkenazi #Jews in wide range of intellectual domains serves as solid refutation to already exhausted #woke narrative of oppression, victimhood, & intersectionality. Why?/1
#IQ #psychology #intelligenceresearch #groupdifferences
"In the first half of the 20th century, despite pervasive and continuing social discrimination against Jews throughout the Western world, despite the retraction of legal rights, and despite the Holocaust, Jews won 14 % of Nobel Prizes in literature, chemistry, physics..."/2
"..., and medicine/physiology. In the second half of the 20th century, when Nobel Prizes began to be awarded to people from all over the world, that figure rose to 29 %. So far, in the 21st century, it has been 32 %. Jews constitute ~0.2 % of the world’s population."/3
