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Do cyclin-dependent kinase (CDK) 4/6 inhibitors cause acute kidney injury (AKI)? #onconephrology #Thread
A little #tweetorial about CDK 4/6 inhibitor-associated AKI: what we know already, and what we found
kireports.org/article/S2468-…
A little #tweetorial about CDK 4/6 inhibitor-associated AKI: what we know already, and what we found
kireports.org/article/S2468-…
3 CDK 4/6 inhibitors (palbociclib, ribociclib, and abemaciclib)have been approved for HER2-negative metastatic breast cancers. CDK 4/6 inhibitors help overcome resistance to endocrine therapies by preventing cell-cycle progression and cancer growth (frontiersin.org/articles/10.33…).
What do we know about AKI related to CDK 4/6 inhibition? In vitro studies suggest that CDK 4/6 inhibitor metabolites inhibit renal transporters, potentially leading to a reversible rise in serum creatinine (SCr) without actually changing GFR (ncbi.nlm.nih.gov/pmc/articles/P…).
