Discover and read the best of Twitter Threads about #HostPathogen
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Extremely exciting findings from @russellevance and @DBachovchin labs on NLRP1 activation following cleavage and degradation of N-terminal fragment now on biorxiv - biorxiv.org/content/early/… and biorxiv.org/content/early/… (1/9)
Destabilization of NLRP1b (e.g. cleavage by bacterial protease or degradation by bacterial ubiquitin ligase) releases non-covalently linked C-terminal fragment that can activate inflammasomes - caspase-1, pyroptosis, IL-1b, the works. (2/9)
Awesome mechanism for maintaining auto inhibition with associated fragments after auto-catalytic cleavage, and exploiting processive nature of the proteasome - using Nlrp1b as a “decoy sensor” sensing its own stability, a molecular "booby trap". (3/9)
