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1) I am a big fan of evolutionary medicine --> the study of human evolution and how it can be harnessed for the practice of medicine.
I recently went in for a deep dive into an important topic --> HYPERURICEMIA
Here is what I learnt!
I recently went in for a deep dive into an important topic --> HYPERURICEMIA
Here is what I learnt!
2) Uric acid is the endproduct of purine metabolism in humans --> this is an exception among mammals!
Why does this happen?
1. Lack of uricase
2. Avid renal reabsorption of uric acid
Why does this happen?
1. Lack of uricase
2. Avid renal reabsorption of uric acid
3) Why happened to uricase?
This ancient enzyme, present since bacteria, accumulated a number of mutations approx 10-30 million years ago and gradually lost its function in humans, some higher primates and some New World monkeys.
pubmed.ncbi.nlm.nih.gov/11961098/
This ancient enzyme, present since bacteria, accumulated a number of mutations approx 10-30 million years ago and gradually lost its function in humans, some higher primates and some New World monkeys.
pubmed.ncbi.nlm.nih.gov/11961098/
