Discover and read the best of Twitter Threads about #Hypoxia
Most recents (15)
It took my legs a few minutes to warm up this morning, but glad to report that long morning walks remain easy, in contrast to later in the day. #Totnes is waking up beautifully ☀️
5 miles walked this morning, with no adverse effects. Then strimmed & mowed a lawn. Great to not be worried about my heart and lungs as I got a real workout from the gardening. However, I'm mindful of the warnings of some with #LongCovid that I should continue to pace myself.
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen 
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!
1) Hypoxemia --> low blood O2 levels.
Hypoxia --> low tissue oxygenation wrt demand
Types of hypoxia
1. Hypoxemic
2. Stagnant
3. Histotoxic
4. Anemic
5. O2 affinity hypoxia
Thanks to @kcolenaj
Hypoxia --> low tissue oxygenation wrt demand
Types of hypoxia
1. Hypoxemic
2. Stagnant
3. Histotoxic
4. Anemic
5. O2 affinity hypoxia
Thanks to @kcolenaj
2) The problem arises if you define O2 content of blood purely as PaO2 or as PaO2+ oxyHb saturation --> for this is the total O2 content of blood.
If we eliminate oxyHb, O2 content of blood becomes less meaningful since the lion's share of O2 is carried by hemoglobin!
If we eliminate oxyHb, O2 content of blood becomes less meaningful since the lion's share of O2 is carried by hemoglobin!
3) If you consider oxyHb + PaO2 in total the anemic and O2 affinity forms of hypoxia must necessarily be a cause of hypoxemic hypoxia --> since anemia (reduced Hb) or increased O2 affinity --> cause HYPOXEMIA!
1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen
2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!
Spent more time in the garden today. Insect populations are booming! A bit of sunshine really helps to lift the spirits.
#Hoverfly
#Hoverfly
Had a run of 3 good days, but just tried doing *some* of the things my lungs had allowed me to do over the weekend & over-did it by fixing the ball-cock in the toilet cistern! Lowered my guard; lungs are tight again (first time in 10 days) & I'm lightheaded. #PulmonaryEmbolism
I want to talk about #LongCovid & #hypoxia & how my experience of it now is *drastically*, even *dangerously* different to what prior lung issues taught me.
I didn't plan to do this thread and I'm not thinking clearly atm, but it's important, so I'm going to give it a go.
I didn't plan to do this thread and I'm not thinking clearly atm, but it's important, so I'm going to give it a go.
Background: I was born prematurely & before synthetic surfactant, so I have asthma and temperamental lungs in general. I also have an extensive history of pneumonias that try to kill me (as in ICU stays). So I've had 40 years of knowing how to handle not being able to breathe.
I knew about happy hypoxia. I knew how, when, and what to do about it when my judgment about whether I was alright started to slip, and I knew that that's often the first thing to go when you're hypoxic - *first*, you feel... off. Unquantifiably off. It's easy to miss it.
We are extremely happy to present our lab’s first #preprint! Together with @teamstembryo we identify #hypoxia as a major microenvironmental factor that governs ES cell lineage commitment.
biorxiv.org/content/10.110…
Short summary 👇🏼👇🏼 (1/11)
biorxiv.org/content/10.110…
Short summary 👇🏼👇🏼 (1/11)
Have you ever wondered how environmental factors such as #hypoxia together with intrinsic cellular regulators shape stem cell identity and differentiation capacity? We have (a lot!). But wait a minute you say, isn’t oxygen essential for mammalian life? (2/11)
Of course it is! But… before placentation, the embryo develops in an increasingly hypoxic environment where oxygen tension is as low as 1.5%. But what’s the physiological relevance? @odedrechavi
(3/11)
(3/11)
Now this is gaining traction !!
#HappyHypoxia .. a situation of low oxygen saturation on the blood, which is an early indicator of impending #COVID19 deterioration !! .. 1/n
Harian Metro, 27/5/2021
hmetro.com.my/amp/mutakhir/2…
#HappyHypoxia .. a situation of low oxygen saturation on the blood, which is an early indicator of impending #COVID19 deterioration !! .. 1/n
Harian Metro, 27/5/2021
hmetro.com.my/amp/mutakhir/2…
An oxygen saturation of below 95% is an indicator of a need to seek further Rx.. if the #COVID19 Px is quarantined at home.. 2/n
Harian Metro, 27/5/2021
hmetro.com.my/amp/mutakhir/2…
Harian Metro, 27/5/2021
hmetro.com.my/amp/mutakhir/2…
Oxygen saturation levels easily measurable using a #pulseoximeter .. easily available at Pharmacies. In fact, currently it's a standard item for those who are under home quarantine for #COVID19 ..
Below is what United Sikhs Malaysia is doing !! .. 3/n
Below is what United Sikhs Malaysia is doing !! .. 3/n
Daily Bookmarks to GAVNet 01/15/2021 greeneracresvaluenetwork.wordpress.com/2021/01/15/dai…
You’ve probably seen or heard about the #PlandemicDocumentary video. It reaches many conclusions that have zero scientific support and are dangerous because they could harm your health. Here are rebuttals and references to just a few of the false claims. A thread. (1/x)
False claim #1: The novel #coronavirus was lab-made.
Truth: Genetic science allows us to understand how and when viruses emerge. Analyses by trusted scientists clearly demonstrates that the virus occurred naturally. (2/x)
Truth: Genetic science allows us to understand how and when viruses emerge. Analyses by trusted scientists clearly demonstrates that the virus occurred naturally. (2/x)
You can read the scientific paper@K_G_Andersen @scrippsresearch; @arambaut; W. Ian Lipkin; @ColumbiaMSPH; @edwardcholmes; & Robert F. Garry @Tulane here (3/x)
nature.com/articles/s4159…,
nature.com/articles/s4159…,
I'd like to point out that while the resolution of a #chronicillness was striking, what is more striking is the rapid descent into Wernicke's in a hospitalized 90 yo woman - a descent so striking that she went into respiratory distress necessitating a #ventilator. 1/
Upon giving #IVthiamine per a #wernickesprotocol at 200mg 3X p/d she woke up, after just 2 days of thiamine treatment, and the ventilator was removed. What could this tell us about the use of thiamine in #COVID19? Perhaps the cluster symptoms we see are really just a variation 2/
thiamine deficiency - one that is being missed by practitioners everywhere because we're not looking at the #mitochondria for answers. 3/
I want to talk about 2 papers that highlight the role of mitochondria in what are likely the progression of symptoms assoc with #COVID19. Note these papers are not about #covid but highlight important pathways. 1/
1st paper - Intracellular ATP is req. 4 #mitochondrial #apoptotic pathways rat #cardiac #myocytes ncbi.nlm.nih.gov/pubmed/12909326 2/
Key findings: apoptosis and necrosis are part of the same pathway, initiated by same mito sequences but are distinguished by time and severity, where the delimiting factor is available intracellular #ATP. 3/
A brief summary of the decision algorithm to hospitalise a patient with suspect #COVID19 in Italy. Relevant to @trishgreenhalgh guidelines for #GP remote assessment
A thread
1/n
A thread
1/n
Patients in respiratory distress affected with #COVID19 arrive with up to severe #hypoxia but usually normocapnia. Therefore no respiratory distress nor hyperventilation
2/n
2/n
Therefore Emergency doctors decide to admit otherwise healthy patients with oxygen saturation below 94% (young patient) or 90-94% (older patient or with chronic lung conditions). For those not falling below the threshold they perform the 40 steps test
3/n
3/n
What's in a name?
Why @WHO's formal name for the new #coronavirus #disease matters:
time.com/5782284/who-na…
#COVID19 #Covid_19
Why @WHO's formal name for the new #coronavirus #disease matters:
time.com/5782284/who-na…
#COVID19 #Covid_19
1. Wash your hands often and/or use hand sanitizer more frequently.
2. Try not to touch your face... 🙈
3. Cough into your shirt or arm.
4. Stay home when you are sick.
5. WASH. YOUR. HANDS!
#COVIDー19
#COVID19
#coronavirus
toronto.citynews.ca/video/2020/02/…
2. Try not to touch your face... 🙈
3. Cough into your shirt or arm.
4. Stay home when you are sick.
5. WASH. YOUR. HANDS!
#COVIDー19
#COVID19
#coronavirus
toronto.citynews.ca/video/2020/02/…
Took me a while, but in response to @AmyPearsonMD tweet of my talk last week @uihealthcare, a thread on ⬆️FiO2 and #SSI.
@scruff888 @DrMikeAziz @MPOGASPIRE @APSForg @woundheal #infectionprevention 1/15
@scruff888 @DrMikeAziz @MPOGASPIRE @APSForg @woundheal #infectionprevention 1/15
Whether intraoperative high inspired oxygen is beneficial is not a settled question.* This thread explains why I routinely use it unless there is a contraindication. bit.ly/2gexBIz
*The evidence that it is NOT harmful is overwhelming.
*The evidence that it is NOT harmful is overwhelming.
Impetus to investigate high-inspired O2 grew out of in vitro, animal, human volunteer, & patient studies (1960s-90s): wound hypoxia associated with⬆️#SSI & peripheral vasoconstriction resulting from SNS activation is common source of wound hypoxia. bit.ly/2H9SlfS
2/15
2/15
