Discover and read the best of Twitter Threads about #ICB

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The latest @HaydnKissick lab paper is out! I am delighted to have worked w/ my mentor, friend, and role model @JennyCarlisleMD as co-first authors to share our latest work in @JITC, detailing features of patients' peripheral and intratumoral response to #ICB in #RCC.
In this study, we study a cohort of 36 #RCC patients receiving immunotherapy at @WinshipAtEmory, and we find that following #ICB, patients often have an identifiable burst of activated T cells in their blood, demonstrated by coexpression of the activation markers CD38 and HLADR.
What was more interesting, though, is that patients with a strong burst in activated T cells also had a positive clinical response to immune checkpoint blockade, shown here by %change in target lesion size and by PFS.
Read 11 tweets
Bigger than #ElChapo bigger than #PabloEscobar 💉💊☠️💰

Big news then, I guess 👀


Huge numbers! $400 billion+ pa 🌎🌍🌏
National security type influence.

Social - Political - Economic

Where does all that money go? 🤔🔁💸
When illegal drug operations get this big, they cross borders, networks become huge & they need protection/assistance

According to well documented incidents, intelligence agencies sometimes oversee 👀

Political expedience
#VangPao #Laos #KhunSa #Golden🔺
There are loads of other well-documented episodes

The untraceable huge sums of 💰 from drugs come in very handy for clandestine funding of "off the books" type operations


When you're fighting for national interests, can it be justified? #ColdWar ImageImageImageImage
Read 7 tweets

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