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Hi #IDTwitter and #MedTwitter! As we near the end of 1st year of ID fellowship @MGHBWHIDFellows , I wanted to reflect on 10 RCTs that I found useful on General ID. This is neither all-encompassing nor meant to get into the meat of study design/critique (#IDJournalClub). (1/12)
1. Staph aureus bacteremia (SAB) is our bread and butter! We are often asked about combination tx. DASH (pubmed.ncbi.nlm.nih.gov/29843781/) did not show benefit to adding daptomycin to beta-lactams for treatment of MSSA SAB. Duration of bacteremia was the primary endpoint. (2/12)
2. What about dreaded MRSA bacteremia? Likewise, CAMERA2 did not show benefit of combo tx w in MRSA SAB and had to be ended early due to AKI in the combo group (jamanetwork.com/journals/jama/…). Synergy with ceftaroline is an upcoming area (journals.asm.org/doi/full/10.11…) (3/12)
