Discover and read the best of Twitter Threads about #IgA

Most recents (5)

#Impfung #sterileImmunität #IgA #intranasaleImpfung
1/n Warum schützen die aktuellen mRNA Impfstoffe zwar vor schwerem Verlauf, aber selbst bei Geboosterten nicht relevant vor Ansteckung bzw. einem pos. PCR Test? Die Antwort ist einfach: IgA! …bzw. dessen Abwesenheit.🧵👇🏻 Image
2/n In dieser schönen Studie nature.com/articles/s4138… wurde untersucht, in welchem Maße nach COVID-Infektion bzw. 2x mRNA Impfung sogenannte IgA-Antikörper (AK) gegen das Spike-Protein (von Sars-CoV-2) nachweisbar sind. Dazu wurden Blut- und Speichelproben analysiert.
3/n Ergebnis: die mRNA Impfstoffe sind in der Lage (blauer Pfeil), eine lokale IgA AK-Sekretion im Speichel auszulösen. Das ist positiv! Denn dieser Typ AK kann auf den Schleimhäuten effektiv das Eintreten von SARS-CoV-2 in die Zellen (des Rachens) verhindern. Was man aber… Image
Read 11 tweets
#Class__Switching

Looking at antibody class switching.
1/ All B cells have the immunoglobulins IgM and IgD on their cell surface. The DNA contains both the information to create these two classes of immunoglobulins. They will be produced in equal amounts during the B cell development.
2/ Once a B cell is activated toward a pathogen, it will begin to secret immunoglobulins (antibodies) in the form of the IgM. This is the only thing it is able to create and secret at this point.
Read 22 tweets
1/6) I am happy to share our preprint where we provide new data regarding the efficiency of Pfizer-BioNTech mRNA Pfizer-BioNTech COVID-19 vaccine in eliciting an antibody response in breastmilk >>>
2/6) This is a product of a fruitful collaboration between Lis Maternity and Women's Hospital, Tel Aviv @SouraskyMedCtr, and the research group of Systems Immunology and Immunotechnology, The @ShmunisR @TelAvivUni >>>
3/6) We describe a cohort of #breastfeeding women who received two doses of the @BNT162b2 @PfizerBioNTech vaccine. For all participants, we collected blood and #breastmilk samples at four time points post-#VaccinationCovid (days 7, 14, 28 35) and monitored >>>
Read 6 tweets
1) Lezione sul #tampone.
Tampone obbligatorio? Attenzione, va fatto bene.
Il virus entra attraverso i micro canali dei vasi e dei nervi olfattivi, ben forniti dei recettori ACE2, che per lui sono indispensabili. (segue)
#coronavirus Image
2) #tampone #coronavirus
Le vie olfattive attraversano naturalmente la lamina cribrosa dell’etmoide e quindi non c’è alcuna necessità di rompere qualcosa per accedere al sistema nervoso.I tamponi, specie se mal fatti, come qualunque traumatismo, aumentano il rischio di infezione
3) #tampone #coronavirus
Anche ferire naso o bocca favorisce le infezioni.
Cute e mucose integre, protette dalle loro secrezioni fisiologiche, proteggono tutte le vie di accesso all'organismo in quanto barriera fisica, chimica e biologica, con cellule specializzate e...
Read 9 tweets
Congrats to Jason (and the rest of the team) on this awesome IgA-deficiency story! biorxiv.org/content/early/… @YaleIBIO #Immunology #Microbiota #IgA #ASAPbio #bioRxiv
It’s been awesome watching this story develop over the last couple years. Truly fantastic effort by the whole group on this intriguing patient cohort, complete with some exciting and new longitudinal data on stability of the microbiota in IgA-deficient patients.
I’ll let the story speak for itself (go read it!) - important work on human immunology and the role of IgA in shaping the gut microbiota. Way to go Jason!
Read 3 tweets

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