Discover and read the best of Twitter Threads about #IgG

Most recents (13)

🧹 Chim Chim Cher-ee 🧹

"Autoimmunity has emerged as a characteristic of the post-COVID syndrome...Latent autoimmunity and polyautoimmunity were found in 83% and 62% of patients, respectively. 3 patients developed an overt autoimmune disease. IgG antibodies against IL-2, CD8B>
and thyroglobulin were found in more than 10% of the patients. Other IgG autoantibodies, such as anti-interferons, were positive in 5–10% of patients. Anti-SARS-CoV-2 IgG antibodies were found in > 85% of patients and were positively correlated with autoantibodies, age, and BMI>
...IgG anti-IFN-λ antibodies were associated with the persistence of respiratory symptoms. In summary, autoimmunity is characteristic of PCS, and latent autoimmunity correlates with humoral response to SARS-CoV-2...In patients with PCS, a proinflammatory state is evident...>
Read 14 tweets
#Class__Switching

Looking at antibody class switching.
1/ All B cells have the immunoglobulins IgM and IgD on their cell surface. The DNA contains both the information to create these two classes of immunoglobulins. They will be produced in equal amounts during the B cell development.
2/ Once a B cell is activated toward a pathogen, it will begin to secret immunoglobulins (antibodies) in the form of the IgM. This is the only thing it is able to create and secret at this point.
Read 22 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Ein Thread: Warum man mindestens die ersten 2 Wochen nach der #Impfung noch sehr vorsichtig sein sollte und warum die Ausdehnung des Impfintervalls auf 6 Wochen für #mRNA Impfstoffe unter den derzeitigen Umständen sinnvoll ist.
Der Aufbau eines Schutzes braucht Zeit...1/n
Nach der Infektion bzw Impfung beginnt das Immunsystem zu arbeiten, es kommt zur Ausbildung spezifischer #Antikörper gegen #SARSCoV2, zuerst #IgM und dann langlebige Antikörper der Klasse #IgG. In der Abbildung sieht man die Bildung der IgG Antikörper nach einer Infektion...2/n Image
Ca 2-3 Wochen nach Infektion sind diese Antikörper nachweisbar (die zeigen übrigens auch bei schwach PCR positiven an, dass eine Infektion vorlag). Nach ca 30 Tagen ist die Konzentration (Titer) am höchsten und dann fällt die Konzentration über Monate hinweg wieder ab...3/n
Read 11 tweets
1/6) I am happy to share our preprint where we provide new data regarding the efficiency of Pfizer-BioNTech mRNA Pfizer-BioNTech COVID-19 vaccine in eliciting an antibody response in breastmilk >>>
2/6) This is a product of a fruitful collaboration between Lis Maternity and Women's Hospital, Tel Aviv @SouraskyMedCtr, and the research group of Systems Immunology and Immunotechnology, The @ShmunisR @TelAvivUni >>>
3/6) We describe a cohort of #breastfeeding women who received two doses of the @BNT162b2 @PfizerBioNTech vaccine. For all participants, we collected blood and #breastmilk samples at four time points post-#VaccinationCovid (days 7, 14, 28 35) and monitored >>>
Read 6 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
Will be an interesting week in many favourites. IG Group is exiting the market in 600-1000 highly speculative companies, and they will be requiring 100% margin from Friday.

What does providing 100% margin buy you? Another 30 days to close positions entirely. They want out. #IGG
IG Group have been notoriously sound with risk management in the past but it does have an effect to those with highly leveraged positions. This is as brutal a change that they have ever come up with though. An immediate jump to 100% margin in so many retail favourites is a killer
IG Group make v little from their small cap stock trading but it’s highly capital intensive. Their prime brokers have forced them into what will be a very unpopular move but I can see other firms following suit. After $GME blew up both short & longs, no-one wants to be bagholder.
Read 5 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
Ahora que están de moda los #anticuerpos y todo el mundo quiere unos por Navidad... Alguna vez os habéis preguntado cómo se producen así de repente cuando te infectas o por qué son efectivos? Os cuento algunas cosas sobre ellos porque es un proceso que MOLA MUCHO⬇️
Los anticuerpos o inmunoglobulinas son producidos por los llamados linfocitos B. Estos son células que se generan en la médula ósea y tienen la capacidad de fabricar anticuerpos. Los anticuerpos son proteínas que se unen de forma específica a los patógenos y los bloquean.
Para que un anticuerpo se produzca tiene que existir un linfocito B que tenga un gen que codifique para ese anticuerpo con la secuencia exacta que haga que se una específicamente a su patógeno.
Read 23 tweets
Senta que lá vem história:
Qual a razão numa pandemia como esta de #COVID19 causada pelo novo #coronavirus para se fazer testes em massa? Siga o fio... 🧗‍♀️🧗‍♂️
A primeira razão p/ ter em larga escala o teste da #PCR (do Inglês polymerase chain reaction test) é poder confirmar de imediato o diagnóstico de portadores de #COVID-19 É determinar quarentena, isolamento social e uma melhor observação evolutiva tanto do doente dos contactantes!
A outra razão importante sobre o #PCR é poder avaliar o material genético do #SARSCoV2 que está naquele momento circulando na comunidade e avaliar por exemplo a existência de mutações na região e/ou país.
Read 6 tweets
2020 weekly close thread for PFAS.

Down 0.17% over the first two trading sessions. 11 up, 9 down, 5 unch...

No movements greater than 5%
Divis #ULS #RECI
Exit: #RRE (too crowded, no edge)
Slice: #AAZ (to 20% weight)

Now 8% cash which I plan to deploy next week

Good w/e all
PFAS down 0.44% weekly (-0.61% YTD). 12 up, 12 down, 2 unch
⭐️ #BVXP #SPSY
🐶 #ULS

New #CAML #IITU
Adds #HICL #TRIG #HFEL #HHI #RECI #PSN #IGG #GSK #KETL #VNET
Divis #GAW #GSK

Have a great w/e folks 🍻🥂⚽️
PFAS up 1.1% weekly (+0.48% YTD). 18 up, 7 down, 2 unch
⭐️ #BVXP #GAW #HICL #IPX #PAY #PSN
🐶 #SPSY #VNET

News #AAZ#CLIG#GAW#PSN

Sold a slither of #GAW & #SPSY to fund an experimental position in #EMQQ

Have a great w/e folks 🍻🥂⚽️
Read 57 tweets
There have been no recent changes to my portfolio holdings, but here's a reminder for anyone who is interested. From largest to smallest. Top five positions = 53% of total. Top 10 = 80%.

#VLE #BRBY #SDHY #HAT #PCF #UCG #DUKE #IGG #CRL #RDL #DIS #NXT #BATS #PKG #REC #DPEU
12 Nov 2018: added #RMV
22 Nov 2018: added #BPM
Read 3 tweets

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