Discover and read the best of Twitter Threads about #Immunology101
Most recents (5)
Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals
Are new variants largely generated in vaccinated or unvaccinated persons?
nature.com/articles/s4146…
Are new variants largely generated in vaccinated or unvaccinated persons?
nature.com/articles/s4146…
Background; knowledge of immunity and virology would indicate that the more a virus replicated, the more chance of mutations and variant selection.
Immunity would reduce replication and selection time.
What did the authors find?
Immunity would reduce replication and selection time.
What did the authors find?
"In unvaccinated individuals, variant of Concern (VOC) Alpha, Delta, and Omicron respiratory samples were found to have higher within-host diversity and were under neutral to purifying selection at the full genome level compared to non-VOC SARS-CoV-2."
Good pre-print!
Viral kinetics of sequential SARS-CoV-2 infections
Comparing primary infection with secondary infection. Is the second one less, more or similarly dangerous?
medrxiv.org/content/10.110…
Viral kinetics of sequential SARS-CoV-2 infections
Comparing primary infection with secondary infection. Is the second one less, more or similarly dangerous?
medrxiv.org/content/10.110…
94,812 longitudinal RT-qPCR measurements from anterior nares and oropharyngeal swabs. Compared the SARS-CoV-2 viral kinetics of first vs. second infections, adjusting for viral variant, vaccination status, and age. 
#immunology101 would strongly suggest that relative to first infections, second infections have reduced pathogen burden, faster clearance, especially in those who received a vaccine dose in addition. But some have contributed near magical properties to SARS-CoV-2.Wee
Some #Immunology101:
A virus infection induces a strong T cell response. In the case of a virus; a type-1 response: involving Th1 cells and CD8 T cells. These cells are known to make the cytokine interferon-gamma (IFNg). They express activation markers, including PD-1.
A virus infection induces a strong T cell response. In the case of a virus; a type-1 response: involving Th1 cells and CD8 T cells. These cells are known to make the cytokine interferon-gamma (IFNg). They express activation markers, including PD-1.
When there is a heavy infection, there is a feedback mechanism. The T cells can now express interleukin-10 (IL-10). IL-10 is an inhibitory cytokine, which will dampen the response to try and limit immune-induced pathology/damage.
journals.aai.org/jimmunol/artic…
journals.aai.org/jimmunol/artic…
This is observed in many type-1 infections, as for SARS here above, and for the Malaria-causing parasite plasmodium here; where the IL-10 can also cause loss of the control of the lung microbiota. This loss of control can cause secondary infections.
nature.com/articles/s4146…
nature.com/articles/s4146…
"Muuh, Bobby, what's up with the #Novak scandal/ @AustralianOpen?"
This is for sure not a #PsyOp, right @DjokerNole?
@novakfoundation supports social impact markets, digital child labour for hedge funds, the #4IR @wef- agenda.
@ProfKlausSchwab approves.
novakdjokovicfoundation.org/davos-2021-hig…
This is for sure not a #PsyOp, right @DjokerNole?
@novakfoundation supports social impact markets, digital child labour for hedge funds, the #4IR @wef- agenda.
@ProfKlausSchwab approves.
novakdjokovicfoundation.org/davos-2021-hig…
Credits for above tweet actually belong to @WWakeUpTime.
Poor @DjokerNole is now isolated at Melbourne Airport.
Will @ProfKlausSchwab/@wef intervene at @AustralianOpen? Is this all just a CheapThrills #Astroturf-#PsyOp for the mainstream normie to seed some Scripted Reality 'predictive programming'? "No Vax, No Winner Cup"? Poll below.
Will @ProfKlausSchwab/@wef intervene at @AustralianOpen? Is this all just a CheapThrills #Astroturf-#PsyOp for the mainstream normie to seed some Scripted Reality 'predictive programming'? "No Vax, No Winner Cup"? Poll below.
Bumping up old memories.
I wonder what happened in Australia all of a sudden, that flipflop was quite accelerated. John? Ian? @ianfmusgrave? What happened?
Did you guys run out of mafia slang?
weforum.org/agenda/authors…
ab.co/3oajIsV
archive.is/sbCVn
I wonder what happened in Australia all of a sudden, that flipflop was quite accelerated. John? Ian? @ianfmusgrave? What happened?
Did you guys run out of mafia slang?
weforum.org/agenda/authors…
ab.co/3oajIsV
archive.is/sbCVn
"One, Two, @dnatured's Coming For You
Three, Four, Better Lock Your Door
Five, Six, Grab A Crucifix
Nine, Ten, Never Sleep Again"
archive.is/sbCVn
Three, Four, Better Lock Your Door
Five, Six, Grab A Crucifix
Nine, Ten, Never Sleep Again"
archive.is/sbCVn
Backflash101: #MackayMafia lobbying for Olfert Landt's shitty Charité/Corman Drosten primers in 🇦🇺.
edition.cnn.com/2020/03/24/asi…
Present: "Great Narrative" Story-Twist?
"Muuuh ref. panel"
bit.ly/3JwfbvL
bit.ly/3qyHp0k
"Muuh Omicron"?
edition.cnn.com/2020/03/24/asi…
Present: "Great Narrative" Story-Twist?
"Muuuh ref. panel"
bit.ly/3JwfbvL
bit.ly/3qyHp0k
"Muuh Omicron"?
