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# Mechanistic therapy on Notch-3 signaling, N-acetyl-cysteine ​​prophylaxis and treatment in pulmonary fibrosis (# sequelacovid19) and other complications. #Immunometabolic
Proteins of the Notch family are cell surface receptors that TRANSDUCE SIGNALS BETWEEN NEIGHBORING CELLS. The Notch signaling pathway is evolutionarily highly conserved, including many aspects of vascular development.
The interaction of Notch receptors with ligands leads to the cleavage of the Notch intracellular domain (NICD) which then translocates to the nucleus and activates the transcription factor CBF1 / JBP-Jkappa, regulating downstream gene expression.
