Discover and read the best of Twitter Threads about #Immunometabolism
Most recents (4)
Now for Dr. @zurisullivan an HHMI Fellow and Fullbright Scholar talking about #NutrientSensing! #BIIW21 #BIIAtTheBench
@zurisullivan We're getting specific on #CarbohydrateDigestion that happens a lot in our #microbiome #BIIW21 #BIIAtTheBench
@zurisullivan Proper controls breed great conclusions: carb availability drives induction of polysaccharide transcriptional programing! #BIIW21 #BIIAtTheBench
#Immunometabolism
PART 1
The general course of events during infections (Sars-CoV2) leading to "cytokine storm" can look like this:
1. Cells undergo damage, senescence, or become infected with a virus.
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PART 1
The general course of events during infections (Sars-CoV2) leading to "cytokine storm" can look like this:
1. Cells undergo damage, senescence, or become infected with a virus.
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2. Those cells release damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs), which activate receptors in the immune system.
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3. DAMPs, like HBGM1, signal the production of the inflammatory response.
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3. DAMPs, like HBGM1, signal the production of the inflammatory response.
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4. HBGM1 binds to TLR2 / TLR4 / RAGE receptors to begin mobilizing pro-inflammatory cytokines.
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5. Activation of the NF-kB / NLRP3 inflammasomes ensues.
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6. Release of pro-inflammatory cytokines IL-1, IL-6, IL-1B, IL-18, IL-17, IL-22, and others occurs.
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5. Activation of the NF-kB / NLRP3 inflammasomes ensues.
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6. Release of pro-inflammatory cytokines IL-1, IL-6, IL-1B, IL-18, IL-17, IL-22, and others occurs.
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Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”: ij.hapres.com/htmls/IJ_1341_…
2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs. 
3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)
1/ I’m hugely excited to be able to share with you our paper ‘hepcidin-mediated hypoferremia disrupts immune responses to vaccination and infection’ @MedCellPress
cell.com/med/fulltext/S…
Thank you @Drakesmith_Lab @MRC_HIU @MRC_WIMM + our global collaborators! #Tweetorial time:
cell.com/med/fulltext/S…
Thank you @Drakesmith_Lab @MRC_HIU @MRC_WIMM + our global collaborators! #Tweetorial time:
2/ We know the immune system responds to nutrient availability #immunometabolism.
#irondeficiency (ID) is the most common micronutrient deficiency globally. How does ID influence immunity?
#irondeficiency (ID) is the most common micronutrient deficiency globally. How does ID influence immunity?
3/ ‘minihepcidin/mHep’ (mimetic of hepcidin) caused serum iron deficiency and suppressed the magnitude/quality of CD8, Tfh, GC and antibody responses to immunisations ⬇️. Injecting iron rescues the effect of ‘mHep’ ⬆️
