Discover and read the best of Twitter Threads about #Isth2022
Most recents (3)
Perioperative #DOAC management. Important differences between PAUSE and ASRA. How can we come to consensus? Dr Douketis is proposing PAUSE-2 trial aiming for a single approach. #ISTH2022 
He performed a small, pilot study to assess feasibility of randomizing to ASRA vs PAUSE approach. High level of consent in this cohort. Will other sites be willing to randomize? I hope so! #ISTH2022
Thrombin generation assays doing a lot of work at non factor therapy for #hemophilia session at #Isth2022 demonstrating
1/4 🧵
1️⃣ Stability of antithrombin knockdown in subjects receiving fitusiran
1/4 🧵
1️⃣ Stability of antithrombin knockdown in subjects receiving fitusiran
2️⃣ Increased potency of Mim8 compared to emicizumab in phase 1 subjects
3️⃣ Potential use of emicizumab in select #hemophilia B patients
SOA live: Dr Zoe McQuiltern on TXA for major bleeding. Surgery/trauma acct for majority of MB but I note worse survival for GIB
#ISTH2022 prehospital STAMP confirms effect size of TXA in trauma from CRASH2 but underpowered. Exploratory analysis suggests Earlier admin within 1h, better outcomes
#ISTH2022 prehospital STAMP confirms effect size of TXA in trauma from CRASH2 but underpowered. Exploratory analysis suggests Earlier admin within 1h, better outcomes
