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Intriguing article in the June issue of @JTOonline by #JongWooLee and @DrRoyHerbstYale tackling the impact of #KRAS on the immune microenvironment in #NSCLC and the rationale for combining #MEK inhibition and anti-PD(L)1 therapy. #OncoAlert #LCSM
jto.org/article/S1556-…
jto.org/article/S1556-…
Authors induced a p53/KRAS G12D mutant NSCLC. Compared to tumor free lungs, see a stark increase in CD45+ cells. Note, geographically localized to periphery/margin. Translational challenge: easy to miss with biopsies(aspirates not helpful). 
Specifically, there’s a rise in neutrophils and MDSCs and a decrease in CD3+/CD8+ T cells in the tumor bearing lung (red bars below). Accompanied by rise in PDL1 expression (in tumor and MDSCs). Story: does this immune cell accumulation precede tumor development? Is it required?
