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Our manuscript on #sarscov2 variant mutations in N is now out in @PLOSPathogens

bit.ly/3n8nO5W

If you are at #KSRNAVirus22 you can talk to 1st author Bryan Johnson about it (probably wearing boots & maybe shorts).

A thread on the paper:
Bryan noticed several mutations in N at pos 203-204, notably a RG->KR found in alpha and omicron & R->M in delta.

The KR mutant in WA1 augmented replication in respiratory cells and disease in vivo.

R203M mutant had similar in vitro phenotype.
We found that the KR mutation increases N phosphorylation and augments viral RNA expression.

This corresponds with larger lesion and antigen staining despite similar titers in vivo.
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