Discover and read the best of Twitter Threads about #Kaletra
Most recents (2)
@afneil The focus on ventilators is about as useful as focusing on whether we have enough coffins. There are more valuable interventions that are being totally ignored in uk at present. Let's run through them:
@afneil 1. Early intervention at home for ALL who develop mild #COVIDー19 symptoms - give them ALL a 5 day course of #chloroquine or #Hydroxychloroquine - this will prevent vast majority of severe cases needing to anywhere near a hospital
@afneil 2. Give PEP - post exposure prophylaxis of #chloroquine or #Hydroxychloroquine to the household members in a home where a person develops symptoms. Evidence is that most transmission is within the household. So stop the virus there!
There is no proven effective antiviral drug for the treatment of #SARSCoV2
Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...
Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...
1/
#Chloroquine
Anti-malaria
Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins
#chloroquine and #redemsivir are active against SARS-COV2 in experimental models
doi.org/10.1038/s41422…
#Chloroquine
Anti-malaria
Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins
#chloroquine and #redemsivir are active against SARS-COV2 in experimental models
doi.org/10.1038/s41422…
2/
#Hydroxychloroquine
- Analogue of chloroquine
- Anti inflammatory effect
Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.
doi.org/10.1093/cid/ci…
#Hydroxychloroquine
- Analogue of chloroquine
- Anti inflammatory effect
Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.
doi.org/10.1093/cid/ci…
