Discover and read the best of Twitter Threads about #KashlakChief

Most recents (7)

1/ How to decipher today's abnormal FBP:

82 yo woman admitted 4 GI bleed (esophageal ulcer) Transfused & volume repleted.
4 days later BMP 142/3.4/112/17/5/0.8
Admission
142/4.2/101/25/45/1.3
#KashlakChief asks
Why is the bicarb 17?
@CPSolvers & @thecurbsiders
2/

She has a bicarbonate of 17 with an anion gap of 13. Her albumin was normal.

Initial assumption - normal gap metabolic acidosis.

Two possibilities - losing base or inability to buffer daily acid
3/
Losing base occurs when we have GI losses. The patient had no diarrhea, no previous Gi surgery, thus this seemed extremely unlikely. Patients with normal renal function need liters of diarrhea to develop this much lowering of their bicarbonate.
Read 11 tweets
1/
Hypokalemic quadriparesis (or severe hypokalemia)
39 yo Egyptian admitted with quadriparesis &K = 1.3
Spend #5goodminutes reading how #KashlakChief conceptualizes &teaches this electrolyte disorder. hope @thecurbsiders and @CPSolvers enjoy & @kidney_boy appropriately critiques
2/
Step 1 determine the acid-base status. Patients can get severe hypokalemia and have normal gap acidosis, normal acid-base or metabolic alkalosis. I am not certain about increased anion gap acidosis, but suspect that some DKA patients have severe hypokalemia.
3/
Let's first understand the normal gap acidosis hypokalemia. There are two major possibilities - distal RTA (Type 1) or diarrhea. We diagnose distal RTA when we have a normal gap acidosis and an elevated urine pH.
Read 16 tweets
1/
Pathergy - several colleagues mentioned this key concept. Search for a precise definition, we use the term to group skin lesions that worsen w/debridement or even just minor trauma.
#KashlakChief presents #5goodminutes & @thecurbsiders & @CPSolvers @uabimres
2/
As the presentation unfolded on Wednesday, the first big clue was that the lesions occurred after seemingly minor scrapes, and then worsened with debridement. The cause of the skin lesions became more complex after we learned that the patient had ESRD on dialysis.
3/
The lesions actually looked similar to calciphylaxis. Two findings (prior to biopsy) made that diagnosis less likely. Her Ca 7.5 (alb 2.2) and Phos 4.5 did not give that high a calcium-phosphate product. Then her CT of the lesions did not show calcium.
Read 7 tweets
1/
#5goodminutes with #KashlakChief
Great case conference, your job = diff dx Questions encouraged.
@thecurbsiders @CPSolvers
2/
60+ woman w/ worsening forearm pain. Fell 1 month ago - forearms developed open sores. Debridement worsened the sores X 2. Antibiotics did not help. Now transferred to your hospital quite sick needing BP support.
3/
Both forearms have large necrotic lesions. She has a new lesion on her abdomen. PMH - ESRD, DM2, CAD, Increased BP - on appropriate meds.
Will answer questions as best I can. Answer with brief tweetorial tomorrow
Read 3 tweets
1/
Spend #5goodminutes thinking about refeeding syndrome with #KashlakChief. Refeeding syndrome actually occurs either with decreased glucose intake or total insulin lack. Who gets this syndrome? I have seen it mostly in alcoholics who eschew food.
2/
Patients with eating disorders (especially anorexia nervosa) or diseases that restrict oral intake (esophageal cancer or stricture or Schatzki ring as examples. You can also get the syndrome from newly diagnosed type I diabetes.
3/
In all these situations, when the 2 components necessary for glycolysis are present (glucose and insulin) the body proceeds. Because these patients have decreased phosphate stores (glycolysis produces ATP) this further decreases serum phosphate levels.
Read 7 tweets
1/
Reciprocal creatinine plots (AKA 1/creatinine vs time) - why internists should understand this concept.
#5goodminutes #KashlakChief @thecurbsiders I hope @kidney_boy will comment and correct any errors
2/
First, this is not a perfect concept, but it is useful for 3 reason. The concept follows from the observation that for most patients, GFR decreases linearly.
3/
Since the creatinine clearance formula has creatinine in the denominator, we can use 1/creatinine as a substitute for estimated GFR. Thus these plots show us the usually relentless progression to ESRD in most patients with significant CKD.
Read 12 tweets
1/ #5goodminutes #KashlakChief has some tweetorial thoughts to add to:
Episode 2 – Hyponatremia – The Clinical Problem Solvers clinicalproblemsolving.com/2018/12/09/epi…
attn @DxRxEdu @CPSolvers @thecurbsiders Please ask for explanations if any of these points are confusing.
2/ Prior to giving saline to hyponatremic patients, please check urine osms. If they are very low (and the serum sodium is very low), you run the danger of overly fast correction and hence demyelination. If the urine osms suggest SIADH, then saline can lower Na significantly
3/ The best explanation for ineffective arterial volume comes from Schrier - here is my blog post from 10 years ago - medrants.com/archives/3480
Read 8 tweets

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