Its not so #cool as it sounds... because of the following,

#Eating #redmeat has been associated with various #health problems, including:
#Cardiovascular disease: High consumption of red meat has been linked to an increased risk of #heart disease due to

1/n

https://twitter.com/DrEliDavid/status/1629182163005370370

the high levels of saturated fat and #cholesterol found in red meat.
#Cancer: Several studies have suggested that high consumption of red meat, particularly processed #meat, can increase the risk of certain cancers, such as colon cancer.
2/n

Type 2 #diabetes: Red meat consumption has been linked to an increased risk of developing type 2 diabetes, potentially due to the high fat content.
#Obesity: High consumption of red meat has been linked to an increased risk of obesity due to its high #calorie and fat content.
3/n

Read 7 tweets

@CKD_ce

@ckd_ce

@dguerrot

1) Welcome to this #accredited #tweetorial on genetic testing in the evaluation of patients with cystic kidney disease. #Kidney #cysts are a frequent finding, ranging from simple cysts to suspected or confirmed #ADPKD.
Expert author @dguerrot of @CHURouen 🇫🇷 leads us!

2) This program is supported by an educational grant from Otsuka Pharmaceuticals & is intended for #HCPs. #Physicians #Physicianassociates #nurses #nursepractioners #pharmacists 🇺🇸🇨🇦🇪🇺🇬🇧 earn CE/#CME credit. Statement of accreditation & faculty disclosures ckd-ce.com/disclosures

3a) Fortuitous discovery of non-malignant kidney cysts is increasingly frequent with age, and often leads to #nephrology referral.

Read 52 tweets

Moneypenny

@nic_moneypenny

Really pleased to share the results of the #LongCovid study I was part of with the Perspectum team out of Oxford University. Using a specialist new technology this focused on assessing multiple organ damage in 'first wave' patients, infected with #COVID in early 2020 or even 2019

We were given in-depth haemotological tests, respiratory assessments and most importantly whole organ scans using the new 'MRI' type enhanced scanning equipment. My first test showed #myocarditis, three liver #lesions, reduced #kidney function and multiple organ inflammation

Also in the first year I experienced #TIA, #atrialfibrillation, #septic bursitis, pre-diabetic symptoms, complete loss of taste & smell; hair loss; #polyarthritis joints, abdominal and bone pain plus multiple #infections and skin eruptions Some neuralgia, headaches and brain fog

Read 5 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

The darker side of dark chocolates

1. Dark chocolates are popular due to their potential health benefits (they are rich in anti-oxidants and are good for heart) and moreover, they are low in sugar content. >50% consider them as safer and healthier option (as compared to candies)

2. But there’s a dark side to this “healthier” #chocolate. Research has found that some dark chocolate bars contain cadmium and lead—two heavy metals linked to a host of health problems.
Consumer report scientists detected cadmium & lead in many dark chocolate samples tested.

3. Consistent, long-term exposure to even small amounts of heavy metals can lead to a variety of #Health problems. The danger is greatest for #pregnantwomen and young #Children because the metals can cause developmental problems, affect #brain development, and lead to lower IQ.

Read 8 tweets

Dr Sudhir Kumar MD DM🇮🇳

@hyderabaddoctor

Are "diet" soft drinks healthy?

1. People are opting for diet soft drinks in place of regular soft drinks, assuming that they are free of sugar, contain zero calories and hence are healthier & safer. But research shows evidence to the contrary.
#MedTwitter #HealthyFood

2a. In two studies conducted in US & Europe, individuals who consumed diet soft drinks had higher prevalence of metabolic syndrome than non-consumers.
Diet soft drink intake positively correlated with waist circumference and fasting plasma glucose in both studies.

2b.
Reference: doi.org/10.3390/nu7053…

Read 14 tweets

Felix Poppelaars

@FPoppelaars

@amjtransplant

A new milestone 🎉: my 3⃣0⃣th publication!

Published @amjtransplant, entitled:
"An interleukin 6-based genetic risk score strengthened with interleukin 10 polymorphisms associated with long-term #kidney allograft outcomes."
➡️pubmed.ncbi.nlm.nih.gov/36453708/

Time for a #tweetorial 🧵👇

1.) Of all #kidney transplants, half are still lost in the first decade after #transplantation.

Using #genetics 🧬, we probed if interleukin 6 (IL-6) could be a target in kidney #transplantation to improve graft survival & if a genetic risk score could improve prognostication.

@marigaya

2.) Together with @marigaya, @VojtechPetr and colleagues from the @GTCumcg & @researchumcg, we studied the impact of IL6, IL6R, IL10, IL10RA & IL10RB 🧬variants on late graft loss by analyzing both recipient and donor DNA of >1,200 #kidney transplant‐pairs.

@YAGroningen @umcg

Read 12 tweets

Beverly G. Tchang, MD

@BevTchangMD

Empagliflozin is now my go-to SGLT2i for pts with #diabetes and #CKD or #CHF, over cana or dapa or ertu.

Why?

A: EMPA-KIDNEY: nejm.org/doi/full/10.10…
and EMPEROR-Reduced and EMPEROR-Preserved
1/

EMPA-KIDNEY is unique because it enrolled GFR 20-45 *without* proteinuria whereas others (DAPA CKD, CANVAS) enrolled pts with CKD+proteinuria, though DAPA-CKD conducted a subgroup analysis for UACR < and > 1000

The primary outcome was a composite of progression of #kidney disease (defined as #ESRD, a sustained decrease in eGFR to <10, a sustained decrease in eGFR of ≥40% from baseline, or death
from #renal causes) or death from #cardiovascular causes

Read 7 tweets

Dr Jaqui Hughes PhD

@jaqui_hughes

@ANZDATARegistry

@ANZDATARegistry annual report about people in Au &Aoetaroa who need life sustaining dialysis/ transplant. this infographic, for community audience, explains how and why Aboriginal and Torres Strait Islander people need #kidney care| anzdata.org.au/wp-content/upl…

@NIKTTaskforce

@NIKTTaskforce (2019-2022), is an #equity intervention to improve kidney transplant access and outcomes for Aboriginal and Torres Strait Islander people. niktt.com.au

@NIKTTaskforce

@NIKTTaskforce works with @TSANZ_txsoc @ANZDATARegistry clinicians & national consumer panel convened by @Keliyari13, a #niktt leader. Our funder, Govt, required us to look into #CulturalBias, niktt.com.au/culturalbias. we worked with @LowitjaInstitut and @UniofAdelaide 👇🏾

Read 9 tweets

cardio-met

@cardiomet_CE

@GiuseppeGalati_

1) Welcome to a new #accredited #tweetorial, Update on New HFrEF Data from ESC 2022 with a Focus on Vericiguat. Our expert author is Giuseppe Galati MD, MMSc in Heart Failure, FHFA, @GiuseppeGalati_ , Consultant #Cardiologist #HeartFailure & #Cardiomyopathies

@GiuseppeGalati_

2) @GiuseppeGalati_ is at San Raffaele Research Hospital, Milan 🇮🇹 @SanRaffaeleMI. This program is intended for #healthcare professionals & is accredited for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists.

3) This program is supported by an educational grant from Bayer. See archived programs still open for credit at cardiometabolic-ce.com. Statement of accreditation & faculty disclosures at cardiometabolic-ce.com/disclosures/.🙏 FOLLOW US !

Read 43 tweets

@CKD_ce

@ckd_ce

@hjanders_hans

1) Welcome to our new #accredited #tweetorial on the Pathophysiology of #DKD in #T2D: Traditional Teaching and New Insights. Our expert author is Hans-Joachim Anders, MD, @hjanders_hans from @LMU_Uniklinikum of @LMU_Muenchen

2) This #accredited #tweetorial series on the foundations of #kidneydisease #DKD through the lens of #T2D is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance and is intended for healthcare providers.

3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Past programs still eligible for credit can be found at ckd-ce.com. Faculty disclosures & accreditation statement are at ckd-ce.com/disclosures/. FOLLOW US!

Read 48 tweets

POH

@POH_Smiles

https://twitter.com/DeclanWaugh/status/1537579339587260416

A good one for this weeks #FluorideFriday. Good find!

https://twitter.com/DeclanWaugh/status/1537579339587260416

#TheyDontKnowAndTheyDoItAnyway. -|- "Conclusions
- Water #fluoridation results in higher plasma #fluoride levels in those with lower #renal function. How routine water #fluoridation may affect the many millions of Americans with Chronic #Kidney Disease, ..."

" ... who are particularly susceptible to heavy metal and mineral accumulation, needs to be further investigated."

Read 8 tweets

cardio-met

@cardiomet_CE

@academiccme

1) Welcome to an #accredited #tweetorial on optimizing the use of #SGLT2i in the management of #T2D. This program is accredited for 0.50 🆓credits for #physicians #nurses #physicianassociates #nursepratcitioners #pharmacists by @academiccme! I am @tmodarressi of @HeartDoctorNJ.

@AndrewJSauer

@AndrewJSauer @DrMichaelShapir @MichaelJBlaha @dramitkhera @pnatarajanmd @PamTaubMD @DrMarthaGulati @DrRaniKhatib @AAgarwalaMD @RpratleyMD @drricardocorrea @AliceYYCheng @SantosGallegoMD @SABOURETCardio @hvanspall @DLBHATTMD @cpcannon

2) This program is intended for healthcare professionals and is supported by an educational grant from Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at cardiometabolic-ce.com.

Read 47 tweets

✨⚫️hgtp://✨Aranka ASKS✨

@ArankaASKS

Thread on #Magnesium and why it is fundamental for our #health. #micronutrients

..many people debate the various ratios of #macronutrients like #protein, #fat, and #carbohydrates in their diet to find their optimal health. Which is great as we are #bioindividuals but most miss out on #micronutrients like #vitamins and #minerals.

The way our bodies are able to use the #macronutrients is fully dependent on how our #enzymatic pathways are influenced by various #micronutrients. One of the most important amongst is #magnesium.

Read 19 tweets

@CKD_ce

@ckd_ce

@hjanders_hans

3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists 🇺🇸🇪🇺🇬🇧🇨🇦. Past programs still eligible for credit are at ckd-ce.com. Faculty disclosures are at ckd-ce.com/disclosures/. FOLLOW US for regular programs by expert faculty!

Read 48 tweets

Truth Signal

@de_bose

@Mktweets0

@Mktweets0 Going to start a thread on #melatonin & its effects on CKD validated by scientific research. Please correct if you find any medical faults.

#kidneys

@Mktweets0

@Mktweets0 1/ Melatonin was first purified and characterised from the bovine pineal gland extract by Aron Lerner and co-workers in 1958.

However it has systemic effects. #Kidney cells (proximal tubule) express a melatonin receptor of type MTNR1. pubmed.ncbi.nlm.nih.gov/9034171/

@Mktweets0

@Mktweets0 2/ Looking at mRNA expression across several human tissues, surprisingly it's rather strongly expressed in colon and #kidney.

genecards.org/cgi-bin/carddi…

Read 12 tweets

Yan Leyfman, MD

@YLeyfman

@salkinstitute

Study from @salkinstitute found that partial reprogramming using the #Yamanaka transcription factors (#Oct4, #Sox2, #Klf4 & #cMyc) for short periods of time:

-restored a youthful #epigenetic signature to #aging cells & extends the life span of a #premature #aging mouse model.

-long-term partial reprogramming led to rejuvenating effects in different tissues, such as the #kidney & #skin, and at the #organismal level; duration of the treatment determined the extent of the beneficial effects.

-The rejuvenating effects were associated with a reversion of the #epigenetic clock and metabolic and #transcriptomic changes, including reduced expression of genes involved in the #inflammation, #senescence & #stressresponse pathways.

nature.com/articles/s4358…

Read 4 tweets

Kyle & Evie 💙 - 🤔 each day's a gift, not a given

@Heretoanywhere

My sincerest & humblest apologies all! For the first time in my life, ever, 9pm, Christmas Eve & i actually just realised what day it was! 😱⚠️
No, i have no idea either but i guess that's what 2 years of near isolation can do to you (throw in painkillers, CF, fibro & depression)

Never assume that because you don't hear from someone everything is ok (the old, "no news is good news" {as all must be ok!}, they're just busy! Especially when it's such a landmark day & ppl are invariably wrapped up with their families. That's not always the case!

Why am i isolating at Christmas? 2 reasons:
🔵 many NHS staff appear to be falling ill despite being triple jabbed &
🔵 Studies seem to be showing effectiveness behind to wane a bit after 10 weeks.

So do you go meet your elderly mum, who's allowing my nephew to shuttle between..

Read 10 tweets

Dr. Andrea Conroy, PhD (she/her)

@AndreaLConroy

This paper has many interesting findings but I wanted to focus on the #brain-#kidney axis. What is the relationship between the kidneys and brain injury in malaria? Can measuring tau levels help us identify children at risk of long-term brain injury? Let's discuss! 🧵

Last year there were an estimated 627 000 malaria deaths with 80% of African deaths occurring in children <5 years of age. Unfortunately, due to COVID-19 disruptions in public health measures to control malaria, this is higher than in previous years.

Survivors are at risk of long-term brain injury. We need tools to identify children at risk of brain injury for early interventions so that every child has an opportunity to survive, and thrive.
who.int/teams/global-m….

Read 16 tweets

@CKD_ce

@ckd_ce

@ckd_ce

Be sure to join us TOMORROW here on @ckd_ce for our first ORIGINAL accredited content . . . from none other than @edgarvlermamd . . . whom you #kidney-oriented clinicians will know as a comforting and familiar presence and as an AWESOME teacher. He'll be talking about ...

@goKDIGO

...IgA nephropathy (#IgAN) from the ... perspective of the 2021 @goKDIGO #guidelines. Lots to learn about this common cause of #CKD worldwide! Free CE/#CME for #physicians #nurses #PAsDoThat #nursepractitioner @ANNAnurses @neph_PAs @pharmacists @nephondemand @IgAN_JBarratt

@NephUCommunity

FOLLOW US NOW so you don't miss a tweet! @NephUCommunity @NephRodby #nephtwitter @ASNKidney @cheekaycheung @dr_denby @geddescc
⁩ @Kidney_Research @UChicagoMed @Renaltubules @kidneypathology @SWadhwaniMD @BradRovin @ssfarouk @arvindcanchi @jopelina @Errantnephron @glomcon

Read 35 tweets

cardio-met

@cardiomet_CE

@GoggleDocs

1)
... more from the #ESCCongress2021 from the @GoggleDocs #Takeover of the @cardiomet_CE

Next up the EMPEROR-Pooled analysis and some of the questions it asks

How does empagliflozin compare with ARNI (sacubitral/valsartan

2)
EMPEROR-Pooled was a prespecified analysis of the two 'sister' studies

EMPEROR-Reduced Trial
nejm.org/doi/full/10.10…

and

EMPEROR-Preserved Trial
nejm.org/doi/full/10.10…

With very similar #HeartFailure populations, separated by an ejection fraction cut off of 40%

3)

As you can see

📍Very similar results in terms of the primary and secondary #HeartFailure outcomes.

‼️ Although clear attenuation of benefit seen in pople with higher ejection fractions (EF)

Read 9 tweets

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