Discover and read the best of Twitter Threads about #Lambda
Most recents (24)
2) #TVG489
Allogenic CAR T cells
These will hopefully be able to clear infected cells, if T cell evasion by SARS-CoV-2 (via MHC I downregulation) can be overcome
labiotech.eu/trends-news/te…
Allogenic CAR T cells
These will hopefully be able to clear infected cells, if T cell evasion by SARS-CoV-2 (via MHC I downregulation) can be overcome
labiotech.eu/trends-news/te…
There was a lot going on in April in terms of meetups all over the world. You can find out more about accessibility, how to learn React Native as a junior, AR apps, using SVG, libraries, debugging and much more!
blog.meetupfeed.io/react-react-na…
blog.meetupfeed.io/react-react-na…
React Native Accessibility Basics via
@explore30666817
Nivedita shares what she has learned about #accessibility and its implication in the past few months. Why should we even care about accessibility?
meetupfeed.io/talk/react-nat…
@explore30666817
Nivedita shares what she has learned about #accessibility and its implication in the past few months. Why should we even care about accessibility?
meetupfeed.io/talk/react-nat…
Learning React Native as a Junior Engineer via
@erinfoox
Learn how you can master #ReactNative as a beginner. What exactly is it? How does it work for #iOS AND #Android?
meetupfeed.io/talk/chain-rea…
@erinfoox
Learn how you can master #ReactNative as a beginner. What exactly is it? How does it work for #iOS AND #Android?
meetupfeed.io/talk/chain-rea…
#Omicron 35 mutaciones
#Lambda 14 mutaciones
#Delta 9 mutaciones
#Mu 9 mutaciones
De todas estas la mas contagiosa es Delta, y tiene 9 mutaciones, tener mas no es sinónimo de ser peor.
Acá una parte de las mutaciones 👇👇👇
#Lambda 14 mutaciones
#Delta 9 mutaciones
#Mu 9 mutaciones
De todas estas la mas contagiosa es Delta, y tiene 9 mutaciones, tener mas no es sinónimo de ser peor.
Acá una parte de las mutaciones 👇👇👇
Lo único que tenemos que ver es si es mas contagiosa, con eso es suficiente para ser peor
Acá la otra parte de las mutaciones 👇👇👇
Acá la otra parte de las mutaciones 👇👇👇
Cuando digo es que suficiente para que sea peor con solo ser mas contagiosa es porque aún manteniendo la tasa de letalidad, al infectar mas gente proporcionalmente irán mas al hospital y fallecerían mas personas.
Quand on entend le porte-parole du Gouvernement qualifier le début de la 5ème vague de "fulgurant", je me dis que :
(a) pas grande chose d'apprise après deux ans de pandémie
(b) faire un peu de maths de base, ne leur fera pas de mal
#Thread
(a) pas grande chose d'apprise après deux ans de pandémie
(b) faire un peu de maths de base, ne leur fera pas de mal
#Thread
Nous sommes un certain nombre à dire depuis l'été dernier "que nous vivons encore et toujours dans une période de pandémie et qu'il serait une erreur de considérer qu’elle est sur le déclin, que le pire est derrière nous". La lecture est surtout en terme des tendances globales🔽
On disait aussi "ns restons sur une compréhension approximative du #SARSCOV2 au niveau biologique & socio comportementale, qui malgré le travail exceptionnel des scientifiques du monde entier, présente tjs des aspects imprédictibles, qu’il faut accepter avec humilité, patience"🔽
Boas notícias:
🔹Vacinas SEGUEM PROTEGENDO contra as versões da variante #Delta (AY.4.2, "Delta Plus" e outras), as variantes #Lambda, #Mu e A.30
🔹Publicado na @NEJM os dados da @pfizer em crianças de 5-11 anos
Venha conferir esse e mais dados no fio! 🧶👇
🔹Vacinas SEGUEM PROTEGENDO contra as versões da variante #Delta (AY.4.2, "Delta Plus" e outras), as variantes #Lambda, #Mu e A.30
🔹Publicado na @NEJM os dados da @pfizer em crianças de 5-11 anos
Venha conferir esse e mais dados no fio! 🧶👇
Um estudo da Dinamarca🇩🇰 demonstrou que, após 2 meses da dose 2 e em comparação com a linhagem B.1 (D614G), a AY.4.2 teve uma redução de 2,3x nos títulos medianos de neutralização, não sendo mais resistente à neutralização em relação a outras versões circulantes da #Delta
Já a variante B.1.617.2 + E484K mostrou uma redução de 4,2x na neutralização, porém é uma variante com menor predominância do que outras versões da #Delta. Essa redução não é superior ao que vemos com a #Beta a qual sabemos que as vacinas geram proteção medrxiv.org/content/10.110…
Muita gente ficou surpresa com as notícias referentes a C.1.2, uma variante possível aumento na transmissão e com algum escape imunológico anunciada pelo Inst. Nacional de Doenças Transmissíveis da 🇿🇦 e da Plataforma de Inov.e Seq. de Pesq. KwaZulu-Natal
Acompanha 🧶👇
Acompanha 🧶👇
RESUMO:
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus
Detalhes👇
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus
Detalhes👇
Não é segredo, nem novidade, que a permanência desse estado de transmissão elevado, que é construído por vários fatores, (baixa cobertura 💉, falta de adesão adequada a medidas como uso de 😷, p.ex), gera um risco de vermos novas variantes surgirem
#COVID19 Une grande difficulté face est de comprendre que cette viralité touche nos modes de vie bien au delà d'une courte période, la plus visible celle des pics. C'est une nouvelle réalité qui doit aller avec une autre pédagogie dans un monde globalisé, interconnecté #Thread
Si nous voulons retrouver de l'apaisement face aux montées des extrémismes, manipulations, un effort d'explication est indispensable pour sortir de NOS certitudes. Le #COVID19 a encore des zones d'ombre, c'est un défi pour la science qui avance à grands pas pour le comprendre /↩️
The Disregard of #InformedConsent and Echoes of Nuremberg Part 2 - “The Great Pivot” - Jab hesitancy is informed, literate, and sophisticated, but government agencies, officials, and politicos pushed false narratives - by @TraderStef 4 #CrushTheStreet #ADE crushthestreet.com/articles/break…
I am moving "The Great Pivot & Echoes of Nuremberg Part 2" #InformedConsent2 (the thread from @RWMaloneMD's gracious RT ) to my acct original here. Replies were breaking apart/not keeping continuity under his RT. Chronology is now intact. Apology for move.
Here is a link to PART 1 of “The Disregard of Informed Consent & Echoes of Nuremberg” (is hash tagged as #InformedConsent). That thread's continuity is intact and extensive, from March 31 to Aug 3.
As atenções voltadas para a #Delta, e precisam estar. A #Delta já é a variante de predominância global, e aqui no 🇧🇷, temos a #Gama até o momento predominante. Será que a #Delta predominaria sobre a #Gama?
Não sabemos, mas pode ter mais "competidoras" nessa história 🧶👇
Não sabemos, mas pode ter mais "competidoras" nessa história 🧶👇
Ainda em Março/21, eu fiz um fio de um brilhante trabalho de vigilância da @fiocruz mostrando que a #Gama (que nos referíamos como P.1 naquele momento) poderia estar sofrendo adaptações em virtude do seu amplo espalhamento no país
Uma breve revisão de porque uma transmissão acelerada tem relação com um risco aumentado em vermos mais variantes surgirem, e dentre elas, alguma(s) que possa(m) nos preocupar
BREAKING🔔 The 3rd preprint from G2P-Japan - we elucidated the evolution and virological phenotype of #Lambda variant (aka C.37 lineage). Lambda is resistant to vaccine-induced antiviral immunity. Please retweet 1/3
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Mutational anaysis showed that a large deletion in the N-terminal domain of the Lambda spike protein (246-253 residues) is responsible for the resiscence to neutralizing antibodies. 2/3
What is Lambda variant?
C.37 - known as Lambda variant is believed to have originated in Peru and deemed “variant of interest” by @WHO June 14.
“There is currently limited evidence available about this variant,” Dr. Alicia Demirjian of PHE told the @BBCNews.
#COVID19 #Lambda
C.37 - known as Lambda variant is believed to have originated in Peru and deemed “variant of interest” by @WHO June 14.
“There is currently limited evidence available about this variant,” Dr. Alicia Demirjian of PHE told the @BBCNews.
#COVID19 #Lambda
Ich verlange von niemanden komplette soziale Isolation.
Ich persönlich hatte seit Beginn der Pandemie konstant soziale Kontakte.
Nur eben: nur eine Hand voll in Präsenz.
Alle möglichst Einzeln, auch nicht alle in einer Woche.
Ich persönlich hatte seit Beginn der Pandemie konstant soziale Kontakte.
Nur eben: nur eine Hand voll in Präsenz.
Alle möglichst Einzeln, auch nicht alle in einer Woche.
Damit, falls doch was passiert, alles übersichtlich bleibt.
Zudem Kontakttagebuch. Mein Maximum war 3 Personen über zwei Wochen. Wobei zwei davon ein Bett teilen.
Zudem Kontakttagebuch. Mein Maximum war 3 Personen über zwei Wochen. Wobei zwei davon ein Bett teilen.
Was auch immer geht: telefonieren. Online spielen. Aber das ist eh meine gängige Kommunikation mit Menschen, die weiter weg wohnen. War ich also schon vor der Pandemie gewohnt.
Un pequeño hilo 🧵 para descansar un poco de la #Deltamanía 🦠😉y seguir explorando el alfabeto griego de Variantes:
👉🏻Hablemos de #LambdaVariant Λ, también llamada #andina por haber sido detectada inicialmente en Perú🇵🇪, y de la q aún sabemos poco
1/10
#VarianteAndina #Lambda
👉🏻Hablemos de #LambdaVariant Λ, también llamada #andina por haber sido detectada inicialmente en Perú🇵🇪, y de la q aún sabemos poco
1/10
#VarianteAndina #Lambda
🦠Empezando por aclarar q entre más oportunidad le demos al virus de seguir replicándose, y al hacerlo encontrar mutaciones q le dan ventaja (infección, escape, virulencia), seguirá retando nuestras medidas de mitigación:
Así q urge ponerle al virus barreras ➡️: 💉+😷+ 🌬
2/
Así q urge ponerle al virus barreras ➡️: 💉+😷+ 🌬
2/
Esta variante Λ se detectó desde 2020 en Perú🇵🇪,…y ya está presente en al menos 31 países, entre los que está México
Importante mencionar q sabemos menos de las variantes detectadas en regiones donde la secuenciación genómica no es tan amplía…
3/
Importante mencionar q sabemos menos de las variantes detectadas en regiones donde la secuenciación genómica no es tan amplía…
3/
Preprint (no revisado por pares aún) de nuestro trabajo sobre eficacia de anticuerpos neutralizantes generados por #CoronaVac (75 muestras) frente a variantes #Lambda (C37), #Gamma (P1) y #Alpha (B117) de #SARSCoV2 #Sinovac
📣medrxiv.org/content/10.110…
📣medrxiv.org/content/10.110…
Variante #Gamma (preocupación) posee 11 mutaciones incluyendo algunas en el sitio de unión al receptor (RBD) asociadas con un incremento en la unión al receptor ACE2 y la infectividad (N501Y) o a la reducción en la eficacia de anticuerpos neutralizantes (K417T and E484K)
Variante #Lambda (interés) tiene un patrón único de 7 mutaciones (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N)
Thread: Wie viele rechte Augenklappen benötigt die hessische Polizeiführung nach mehr als 100 Verfahren gegen PolizistInnen, die kein rechtes Netzwerk erkennen möchte? Ein intimer Blick ins #SEK. 1/x #Frankfurt #Polizeiskandal #Hanau #Lambda #IB #Bereswill
Nur mal für den aktuellen Blick, auf den jüngsten #Polizeiskandal & dessen bis jetzt bekannten Ausmaß: 49 Polizeibeamte, 2 ehemalige Polizisten, 5 externe Personen, in insgesamt 7 #Chatgruppen, die #rechtsextreme Inhalte austauschten. #Frankfurt #SEK 2/x
Der seit 2014 eingesetzte Polizeipräsident Gerhard #Bereswill ist als verantwortlicher Polizeipräsident von #Frankfurt nicht haltbar. Unter seiner Führung sind mehr als 100 Verfahren gegen seine #Polizei-BeamtInnen wegen #Rechtsextremismus uvw. eingeleitet worden. #SEK 3/x
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Logik zum #Öffnungsplan der #Bundesregierung
Wo, wie und wie schnell infiziert man sich mit dem #Coronavirus? Solange die Regierung Entscheidungen - magels Datenlage - ohne Evidenz trifft, solange ist es Willkür, wann welche Bereiche geöffnet und andere geschlossen bleiben #Spahn
Wo, wie und wie schnell infiziert man sich mit dem #Coronavirus? Solange die Regierung Entscheidungen - magels Datenlage - ohne Evidenz trifft, solange ist es Willkür, wann welche Bereiche geöffnet und andere geschlossen bleiben #Spahn
Die Mutante #B117 erreicht in diesen Tagen -in den ersten Bundesländern- ihre #Dominanz. #R steigt zeitgleich und die #Regierung erhöht per #Öffnungsplan die #Mobilität: B117, Öffnungsplan u. gesteigerte Mobilität sind drei Faktoren die logisch #R exponentiell beeinflussen können
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
Excited for my first re:Invent and getting ready for the @ajassy keynote coming up!
reinvent.awsevents.com
#awsreinvent #AWS #cloud
reinvent.awsevents.com
#awsreinvent #AWS #cloud
Loving the opening music act 🎸
Zach Person is the musician playing, so awesome...
Here is his Instagram - instagram.com/zachperson/
Here is his Instagram - instagram.com/zachperson/
I know "serverless" is sometimes called out as a buzzword, but the model #AWS #Lambda introduced quite literally changed my career (and consequently, my life). (Thread)
A few years ago, I started an open source security auditing tool called CloudSploit. It got a lot of users, but many were asking me if I could offer a hosted version as an API (and they were willing to pay for it!).
I had some experience with server side dev, but CloudSploit had unique challenges. It would have to horizontally scale out / back very quickly as it was running these security scans. I built a quick set of services using EC2, but it quickly became expensive and hard to manage.
What are some database engines that works great with serverless architecture?
#database #CodeNewbie #Serverless #javascript
#database #CodeNewbie #Serverless #javascript
Note to Self: MongoDB can be used with serverless functions by caching the initial connection.
database engines were designed much before the serverless architecture was a thing.
a connection to the database is always persistent. meaning, it lasts for a really long time.
database engines were designed much before the serverless architecture was a thing.
a connection to the database is always persistent. meaning, it lasts for a really long time.
also, there is a limit(imposed by DBaaS provider) on how many connections a database can have at any given timestamp.
a lambda function is invoked every time a client(generally, browsers) creates a connection. this means a new connection to the database as well.
a lambda function is invoked every time a client(generally, browsers) creates a connection. this means a new connection to the database as well.
Hoy me gustaría compartir algunas reflexiones fruto de las últimas novedades aparecidas y mis experiencias en cliente con #infrastructureascode en #AWS. Vamos al lío 👇
Siempre me he sentido más atraido hacia el enfoque declarativo por su falsa sensación de control y orden, pero con configuraciones grandes, poder refactorizar el código hacia abstracciones propias y modificar su definición/parametrización con código ha sido determinante
En ese sentido, #cloudformation como tal siempre me ha parecido muy locura y un formato más de bajo nivel que otra cosa. En general siempre trabajo con herramientas que lo generan como #serverlessframework o #amplify
