Discover and read the best of Twitter Threads about #Leronlimab
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One of the most effective clinically proven CCR5 chemokine receptor antagonists is #Leronlimab.
Why is this drug really a "game changer" in severe COVID-19?
I will try to explain it in a short thread
Why is this drug really a "game changer" in severe COVID-19?
I will try to explain it in a short thread
Briefly, CCR5 is a chemokine receptor able to bind to key leukocyte recruitment factors such as macrophage inflammatory protein (MIP)-1α, MIP-1β, and RANTES (T-cell secreted CCL5), thus, regulating leucocyte trafficking to normal and inflamed tissues.
nature.com/articles/nrneu…
nature.com/articles/nrneu…
In many pathological situations, such as rheumatoid arthritis (RA), multiple sclerosis or graft rejection, CCR5 expressing cells, such as effector T cells, are found in great numbers into the inflammation sites, where CCR5 binding chemokines are produced
linkedin.com/posts/elard-s-…
linkedin.com/posts/elard-s-…
#Leronlimab is an antibody that blocks a cell receptor called CCR5. The #CCR5 receptor just happens to be a key doorway HIV uses to get inside a cell so that’s why we developed it as an HIV treatment. But the actual function of CCR5 inside our body is to direct cell movement and
Function. Breast, prostate, and a few other cancers co-opt the immune system to support their growth by using the CCR5 receptor to control cell movement and function. We were targeting that role of CCR5 to support cancer cell growth when COVID-19 hit. Our early signals of success
in breast cancer led us to believe we could impact the inflammation, or #cytokinestorm, that is killing patients with Covid-19 since it is the same cell movement and function controlled by CCR5 that is involved. And, as incredible as it sounds, I believe we got very lucky and
$CYDY @CytoDyn 's #leronlimab is the most effective #COVID__19 therapy in that it:
💉 quiets the cytokine storm,
💉restores the immune response
💉 shuts off the virus.
seekingalpha.com/article/435514…
💉 quiets the cytokine storm,
💉restores the immune response
💉 shuts off the virus.
seekingalpha.com/article/435514…
$CYDY #leronlimab blocks the binding of RANTES to immune cells, preventing mass migration of cells causing damage & the release of proteins causing cytokine storm; it restores the immunosuppressant, taking CD8 cells back to normal. Then it knocked the viral load to 0 in 14 days
$CYDY After seeing results from 100s of patients over weeks of therapy, Dr. Patterson is optimistic. He has observed that #leronlimab may make #COVID a viral disease instead of an immunological disease if administered early, & if administered later, it can repair virus damage.
offering comprehensive #cytokine profiling (including RANTES levels), to help Drs understand the pathogenesis of Childhood Inflammatory Disease Related to #COVID19 #Leronlimab pdf.reuters.com/htmlnews/htmln…
Recent reports in parts of the U.S. and Europe suggest a rare and potentially fatal inflammatory disease linked to #coronavirus is afflicting a small number of children. #Leronlimab may be able to help calm #CytokineStorm
Condition resembles a rare childhood illness called #KawasakiDisease, which has similar signs and symptoms and can lead to enlargement of blood vessels that in severe forms may cause heart damage. #Leronlimab has shown to help calm #CytokineStorm and maybe good #treatment
