Discover and read the best of Twitter Threads about #Lesionsegregation
Most recents (4)
Switching gears from covid-centric to #cancer, where there have been a flurry of important papers in the past week
1. "Our discovery of #lesionsegregation challenges longstanding assumptions of cancer evolution"
nature.com/articles/s4158… @nature
media.nature.com/original/magaz… @NatureNews
1. "Our discovery of #lesionsegregation challenges longstanding assumptions of cancer evolution"
nature.com/articles/s4158… @nature
media.nature.com/original/magaz… @NatureNews
2. 2 new papers on clonal hematopoiesis, which is associated with increased risk of cancer and heart disease
nature.com/articles/s4158…
nature.com/articles/s4158…
nature.com/articles/s4158…
nature.com/articles/s4158…
3. 2 reports on using methylomes to detect or track cancer, one using plasma tDNA for brain tumors, the other urine and plasma for kidney cancer
@NatureMedicine
nature.com/articles/s4159…
nature.com/articles/s4159…
@NatureMedicine
nature.com/articles/s4159…
nature.com/articles/s4159…
Researchers from the @bbglab at @IRBBarcelona have contributed to the discovery of #LesionSegregation, explaining how DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.
➡️bit.ly/2Nv8u1c
by: @emblebi
(1/5)
➡️bit.ly/2Nv8u1c
by: @emblebi
(1/5)
The work has been published in the journal @nature.
“This process, which we named #lesionsegregation, is very revealing to understand how mutations occur, a key step in the evolution of cancer,” says @nlbigas.
(2/5)
“This process, which we named #lesionsegregation, is very revealing to understand how mutations occur, a key step in the evolution of cancer,” says @nlbigas.
(2/5)
“Persistent DNA lesions induced by chemotherapeutic agents segregate and produce several generations of further mutations. We need to be aware of this therapeutically, and in future drug development," explains @mst_paralogue from @EdinburghUni.
(3/5)
(3/5)
We are really excited that our work showing how pervasive lesion segregation shapes cancer genome evolution is published today in @nature.
nature.com/articles/s4158…
Here’s a #tweetorial to explain our #LesionSegregation findings...
[1/13]
nature.com/articles/s4158…
Here’s a #tweetorial to explain our #LesionSegregation findings...
[1/13]
Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity hinders our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
[2/13]
[2/13]
WGS of mutagen-initiated tumours showed a high burden of point mutations, comparable to human cancers caused by exogenous mutagens, e.g. lung and skin cancer. The tumours are dominated by thymine mutations (“DEN signature”) and driver mutations in the EGFR-RAS-RAF pathway.
[3/13]
[3/13]
We are really excited to share our work on how Pervasive lesion segregation shapes cancer genome evolution @biorxivpreprint.
Here’s a #tweetorial to explain our #LesionSegregation findings...
biorxiv.org/content/10.110…
Thread, 1/11
Here’s a #tweetorial to explain our #LesionSegregation findings...
biorxiv.org/content/10.110…
Thread, 1/11
Human cancer genomes are unavoidably confounded by genetic and environmental differences. Such intrinsic heterogeneity confounds our ability to disentangle biases of DNA damage and repair. So we used an in vivo oncogenesis model to re-run cancer evolution hundreds of times.
2/11
2/11
WGS of these mutagen-initiated tumours had a high burden of point mutations, comparable to cancers caused by exogenous mutagens, eg lung and skin cancer. The tumours are dominated by Thymine mutations - the “DEN signature” - and driver mutations in the EGFR/RAS/RAF pathway.
3/11
3/11
