Discover and read the best of Twitter Threads about #Letermovir
Most recents (2)
Hey #hematology aspirants, let's talk about #CMV today !! Post allogenic transplant CMV prophylaxis and pre-emptive therapy to be precise.
A short thread 🧵
1/n
#MedTwitter #MedEd #hematology
A short thread 🧵
1/n
#MedTwitter #MedEd #hematology
CMV a DNA virus, one of the commonest causes of infections post HSCT
Has the largest genome of any known human virus [200 genes]
Most humans harbour latent CMV, infection aquired in childhood.
Site of latency in humans-❓
In murine models- hepatic sinusoidal cells.
2/n
Has the largest genome of any known human virus [200 genes]
Most humans harbour latent CMV, infection aquired in childhood.
Site of latency in humans-❓
In murine models- hepatic sinusoidal cells.
2/n
The risk of reactivation depends on CMV sero status:
D-/R+ > D+/R+ > D+/ R- > D- / R -
Other risk factors are:
1️⃣T cell depletion
2️⃣HaploSCT
3️⃣UCB SCT
4️⃣GVHD requiring steroids
So why not give prophylaxis to these "high-risk" patients ??
3/n
D-/R+ > D+/R+ > D+/ R- > D- / R -
Other risk factors are:
1️⃣T cell depletion
2️⃣HaploSCT
3️⃣UCB SCT
4️⃣GVHD requiring steroids
So why not give prophylaxis to these "high-risk" patients ??
3/n
Humanity has always struggled to fight #viruses , best exemplified by the ongoing #Covid_19 #pandemic ,so I thought of doing a thread on a #virus which frequently troubles #hematology patients
It's called #CMV or #HHV5
It wrecks havoc #posttransplant
#MedTwitter @BloodJournal
It's called #CMV or #HHV5
It wrecks havoc #posttransplant
#MedTwitter @BloodJournal
⚡DNA virus ,1 of the MC infections post SCT
⚡It has the largest genome of any known human virus [230kb /200 genes]
⚡Most humans harbour latent CMV, infection MC aquired in childhood.
⚡Site of latency in humans- Not Known
In murine models - hepatic sinusoidal cells
⚡It has the largest genome of any known human virus [230kb /200 genes]
⚡Most humans harbour latent CMV, infection MC aquired in childhood.
⚡Site of latency in humans- Not Known
In murine models - hepatic sinusoidal cells
⚡The risk of reactivation depends on CMV sero status and is as follows:
D-/R+ > D+/R+ > D+/ R- > D- / R -
⚡The other risk factors are
1️⃣ T cell depletion
2️⃣ HaploSCT
3️⃣ UCB SCT
4️⃣ GVHD requiring Rx
⚡ So why not give prophylaxis to these patients ??
D-/R+ > D+/R+ > D+/ R- > D- / R -
⚡The other risk factors are
1️⃣ T cell depletion
2️⃣ HaploSCT
3️⃣ UCB SCT
4️⃣ GVHD requiring Rx
⚡ So why not give prophylaxis to these patients ??
